Journal of Voice
Volume 23, Issue 6 , Pages 721-725 , November 2009

Is Reinke's Edema a Precancerous Lesion? Histological and Electron Microscopic Aspects

  • Regina Helena Garcia Martins

      Affiliations

    • Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, Botucatu Medical School, Unesp-São Paulo State University, Brazil
    • Corresponding Author InformationAddress correspondence and reprint requests to Regina H.G. Martins, MD, PhD, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Faculdade de Medicina de Botucatu - UNESP, Distrito de Rubião Júnior, 18618-970, Botucatu, SP, Brazil.
    • ,
  • Alexandre Todorovic Fabro

      Affiliations

    • Department of Pathology, Botucatu Medical School, Unesp-São Paulo State University, Brazil
    • ,
  • Maria Aparecida Custódio Domingues

      Affiliations

    • Department of Pathology, Botucatu Medical School, Unesp-São Paulo State University, Brazil
    • ,
  • Andréa Peiyun Chi

      Affiliations

    • Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, Botucatu Medical School, Unesp-São Paulo State University, Brazil
    • ,
  • Elisa Aparecida Gregório

      Affiliations

    • Department of Morphology (Gregório) - Botucatu Medical School, Unesp-São Paulo State University, Brazil

,Accepted 3 March 2008.

References 

  1. Garcia Alvarez CD, Campos Banales ME, Lopes Campos D, Rivero J, Perez Pinero B, Lopes Aguado D. Polyps, nodules and Reinke edema. An epidemiological and histopathological study. Acta Otorrinolaringol Esp. 1999;50:443–447
  2. Marcotullio D, Magliulo G, Pezone T. Reinke's and risk factors: clinical and histopathologic aspects. Am J Otolaryngol. 2002;23:81–84
  3. Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg. 2000;123:385–388
  4. Remacle M, Degols JC, Delos M. Exudative lesions of Reinke's space. An anatomopathological correlation. Acta Otorhinolaryngol Belg. 1996;50:253–264
  5. Dikkers FG, Nikkels PGJ. Benign lesions of the vocal folds: histopathology and phonotrauma. Ann Otol Rhinol Laryngol. 1995;104:698–703
  6. Marcotullio D, Magliulo G, Pietrunti S, Suriano M. Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing. J Otolaryngol. 2002;31:376–380
  7. Cervera-Paz FG, Dikkers FG. Ultraestructura y patogenia de las lesions fonatorias de las cuerdas vocales. Acta Otorrinolaringol Esp. 1994;45:261–265
  8. Dikkers FG, Hulstaert CE, Oosterbaan JA, Cervera-Paz FJ. Ultrastructural changes of the basement membrane zone in benign lesions of the vocal folds. Acta Otolaryngol (Stockh). 1993;113:98–101
  9. Gray SD, Hammond E, Hanson DF. Benign pathologic responses of the larynx. Ann Otol Rhinol Laryngol. 1995;104:13–18
  10. Courey M, Scott MA, Shohet JA, Ossoff RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol. 1996;105:525–531
  11. Neves BMJ, Neto JG, Pontes P. Diferenciação histopatológica e imunoistoquímica das alterações epiteliais no nódulo vocal em relação aos pólipos e ao edema de Reinke. Rev Bras Otorrinolaringol. 2004;4:439–448
  12. Volic SV, Kirincic N, Markov D. Some morphological, histological, cytological and histochemical aspects of Reinke's oedema. Acta Otolaryngol (Stockh). 1996;16:322–324
  13. Pastuszek P, Krecicki T, Zalesska-Krecicka M, Jelen M, Rak J, Krajewska B. Histological and electron microscopic investigation of Reinke's edema. Pol J Pathol. 2003;54:61–64
  14. Hellquist H, Lundgren J, Olofsson J. Hiperplasia, keratosis, dysplasia and carcinoma in situ of the vocal cords—a follow up study. Clin Otolaryngol. 1982;7:11–27
  15. Scheuffler H. Reinke ödem und larynx-carcinom. HNO. 1961;9:337–339
  16. Gale N, Pich BZ, Sidransky D, Westra WH, Califano J. Tumours of the hipopharynx, larynx and trachea. In:  Barnes L,  Everson JW,  Reichart P,  Sidransky D editor. World Health Organization Classification of Tumors. Pathology & Genetics. Head and Neck Tumours. Iarc Press Lyon; 2005;p. 140–145
  17. Eggemann G. Maligne entartung eines Reinke-stimmband-ödems. Z Laryngol Rhinol Otol. 1970;49:300–302
  18. Nielsen VM, Hojslet PE, Palvio D. Reinke's oedema: a premalignant condition?. J Laryngol Otol. 1986;100:1159–1162

PII: S0892-1997(08)00041-6

doi: 10.1016/j.jvoice.2008.03.001

Journal of Voice
Volume 23, Issue 6 , Pages 721-725 , November 2009

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