Journal of Voice
Volume 24, Issue 5 , Pages 531-539 , September 2010

Vocal Fold Nodules: Morphological and Immunohistochemical Investigations

  • Regina Helena Garcia Martins

      Affiliations

    • Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • Corresponding Author InformationAddress correspondence and reprint requests to Regina Helena Garcia Martins, Disciplina de Otorrinolaringologia, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço da Faculdade de Medicina de Botucatu, Distrito de Rubião Junior, Botucatu, São Paulo, Brazil.
    • ,
  • Julio Defaveri

      Affiliations

    • Department of Pathology, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • ,
  • Maria Aparecida Custódio Domingues

      Affiliations

    • Department of Pathology, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • ,
  • Rafael de Albuquerque e Silva

      Affiliations

    • Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • ,
  • Alexandre Fabro

      Affiliations

    • Department of Pathology, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil

,Accepted 6 January 2009.

References 

  1. Garcia Alvarez CD, Campos Banales ME, Lopes Campos D, Rivero J, Perez Pinero B, Lopes Aguado D. Polyps, nodules and Reinke edema. An epidemiological and histopathological study. Acta Otorrinolaringol Esp. 1999;50:443–447
  2. Cervantes O, Abrahão M. O nódulo vocal: conceitos atuais. Rev Bras Otorrinolaringol. 1995;2:12–17
  3. Dejonchere PH. Voice problems in children. Pathogenesis and diagnosis. Int J Pediatr Otorhinolaryngol. 1999;49:311–314
  4. Carding PN, Roulstone S, Northstone K. The prevalence of childhood dysphonia: a cross-sectional study. J Voice. 2006;20:623–630
  5. Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg. 2000;123:385–388
  6. Meirelles RG. Obstrução nasal e nódulos vocais. Rev Bras Otorrinolaringol. 2001;67:387–392
  7. Kantas I, Balatsouras DG, Kamargianis N, Katotomichelakis M, Riga M, Danielidis V. The influence of laryngopharyngeal reflux in the healing of laryngeal trauma. Eur Arch Otorhinolaryngol. 2009;266:253–259
  8. Sapir S, Keidar A, Mathers-Schmidt B. Vocal attrition in teachers: survey findings. Eur J Disord Commun. 1993;28:177–185
  9. Urrutikoetxea A, Ispizua A, Madellanes F. Pathologie vocale les professeurs: une etude vidéo-laryngo-stroboscopique de 1046 professeurs. Rev Laryngol Otol Rhinol (Bord). 1995;11:255–262
  10. Quintairos S. Incidência de nódulos vocais em professores de pré-escola e seu tratamento. Rev CEFAC. 2000;2:6–22
  11. Tavares ELM, Martins RHG. Avaliação vocal de professores. J Voice. 2007;21:407–414
  12. de Araújo TM, dos Reis EJ, Carvalho FM, Porto LA, Reis IC, de Andrade JM. Factors associated with voice disorders among women teachers. Cad Saude Publica. 2008;24:1229–1238
  13. Dikkers FG, Hulstaert CE, Oosterbaan JA, Cervera-Paz FJ. Ultrastructural changes of the basement membrane zone in benign lesions of the vocal folds. Acta Otolaryngol. 1993;113:98–101
  14. Remacle M, Degols JC, Delos M. Exudative lesions of Reinke's space. An anatomopathological correlation. Acta Otorhinolaryngol Belg. 1996;50:253–264
  15. Dikkers FG, Nikkels PGJ. Benign lesions of the vocal folds: histopathology and phonotrauma. Ann Otol Rhinol Laryngol. 1995;104:698–703
  16. Gray SD, Hammond E, Hanson DF. Benign pathologic responses of the larynx. Ann Otol Rhinol Laryngol. 1995;104:13–18
  17. Marcotullio D, Magliulo G, Pietrunti S, Suriano M. Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing. J Otolaryngol. 2002;31:376–380
  18. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981;29:577–580
  19. Gale N, Zidar N, Fischinger J, Kambic V. Clinical applicability of the Ljubljana classification of epithelial hyperplasic laryngeal lesions. Clin Otolaryngol Allied Sci. 2000;25:227–232
  20. Czerwonka L, Jiang JJ, Tao C. Vocal nodules and edema may be due to vibration-induced rises in capillary pressure. Laryngoscope. 2008;118:748–752
  21. Gray S, Titze I. Histologic investigation of hyperphonated canine vocal cords. Ann Otol Rhinol Laryngol. 1988;97:381–389
  22. Pastuszek P, Krecicki T, Zalesska-Krecicka M, Jelen M, Rak J, Krajewska B. Histological and electron microscopic investigation of Reinke's edema. Pol J Pathol. 2003;54:61–64
  23. Volic SV, Kaplan I, Seiwerth S, Ibrahimpasic T. Extracellular matrix of Reinke's space in some pathological conditions. Acta Otolaryngol. 2004;124:505–508
  24. Courey M, Scott MA, Shohet JA, Ossoff RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol. 1996;105:525–531
  25. Neves BMJ, Neto JG, Pontes P. Diferenciação histopatológica e imunoistoquímica das alterações epiteliais no nódulo vocal em relação aos pólipos e ao edema de laringe. Rev Bras Otorrinolaringol. 2004;70:439–448
  26. Gray SD, Pignatari SHSN, Harding P. Morphologic ultrastructure of anchoring fibers in normal vocal folds basement membrane zone. J Voice. 1994;8:48–52
  27. Tillmann BL, Li W, Gray SD, Chen Z. Instability of extracellular matrix gene expression in primary cell culture of fibroblasts from human vocal fold lamina propria and tracheal scar. Ann Otol Rhinol Laryngol. 2002;111:8–14

 Financial support was provided by FAPESP.

PII: S0892-1997(09)00007-1

doi: 10.1016/j.jvoice.2009.01.002

Journal of Voice
Volume 24, Issue 5 , Pages 531-539 , September 2010

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