Journal of Voice
Volume 25, Issue 1 , Pages 98-106 , January 2011

Vocal Polyps: Clinical, Morphological, and Immunohistochemical Aspects

  • Regina Helena Garcia Martins

      Affiliations

    • Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • Corresponding Author InformationAddress correspondence and reprint requests to Regina Helena Garcia Martins, Disciplina de Otorrinolaringologia, Departamento de Oftalmologia, Otorrinolaringologia e Cirurgia de Cabeça e Pescoço da Faculdade de Medicina de Botucatu, Distrito de Rubião Junior, Botucatu (SP), CEP: 18618-970, Brazil.
    • ,
  • Julio Defaveri

      Affiliations

    • Department of Pathology, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • ,
  • Maria Aparecida Custódio Domingues

      Affiliations

    • Department of Pathology, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil
    • ,
  • Rafael de Albuquerque e Silva

      Affiliations

    • Department of Otorhinolaryngology, Ophthalmology and Head and Neck Surgery, School of Medicine, São Paulo State University, Botucatu, São Paulo, Brazil

,Accepted 5 May 2009.

References 

  1. Behlau M, Madazio G, Pontes P. Disfonias Organofuncionais. In:  Behlau M editors. Voz: o livro do especialista. Rio de Janeiro: Revinter; 2001;p. 295–341
  2. Michael MJ. Update on the etiology, diagnosis, and treatment of vocal fold nodules, polyps, and cysts. Curr Opin Otolaryngol Head Neck Surg. 2003;11:456–461
  3. Kantas I, Balatsouras DG, Kamargianis N, Katotomichelakis M, Riga M, Danielidis V. The influence of laryngopharyngeal reflux in the healing of laryngeal trauma. Eur Arch Otorhinolaryngol. 2009;266:253–259
  4. Kambic V, Radsei Z, Zargi M, Acko M. Vocal cord polyps: incidence, histology and pathogenesis. J Laryngol Otol. 1981;95:609–619
  5. Dikkers FG, Nikkels Pgj. Benign lesions of the vocal folds: histopathology and phonotrauma. Ann Otol Rhinol Laryngol. 1995;104:698–703
  6. Remacle M, Lagneau E, Doylen A, Marbaix E. Exudative laryngeal diseases of Reinke's space. Ann Otolaryngol Chir Cervicofac. 1995;109:33–38
  7. Garcia Alvarez CD, Campos Banales ME, Lópes Campos D, Rivero J, Péres Pinero B, Lópes Aguado D. Polyps, nodules and Reinke edema. An epidemiological and histopathological study. Acta Otolaryngol Esp. 1999;50:443–447
  8. Remacle M, Degols JC, Delos M. Exudative lesions of Reinke's space. An anatomopathological correlation. Acta Otorhinolaryngol Belg. 1996;50:253–264
  9. Volic SV, Kaplan I, Seiwerth S, Ibrahimpasic T. Extracellular matrix of Reinke's space in some pathological conditions. Acta Otolaryngol. 2004;124:505–508
  10. Dikkers FG, Hulstaert CE, Oosterbaan JA, Cervera-Paz FJ. Ultrastructural changes of the basement membrane zone in benign lesions of the vocal folds. Acta Otolaryngol (Stockh). 1993;113:98–101
  11. Cervera-Paz FG, Dikkers FG. Ultraestructura y patogenia de las lesions fonatorias de las cuerdas vocales. Acta Otorrinolaringol Esp. 1994;45:261–265
  12. Gray SD, Hammond E, Hanson DF. Benign pathologic responses of the larynx. Ann Otol Rhinol Laryngol. 1995;104:13–18
  13. Huang DY, Yang WY, Sun JH, Han DY. Electron microscopic observation of vocal fold polyps. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2008;43:287–290
  14. Courey M, Scott MA, Shohet JA, Ossoff RH. Immunohistochemical characterization of benign laryngeal lesions. Ann Otol Rhinol Laryngol. 1996;105:525–531
  15. Neves BMJ, Neto JG, Pontes P. Diferenciação histopatológica e imunoistoquímica das alterações epiteliais no nódulo vocal em relação aos pólipos e ao edema de laringe. Rev Bras Otorrinolaringol. 2004;70:439–448
  16. Martins RHG, Fabro AT, Domingues MAC, Chi AP, Gregório EA. Is Reinke's edema a precancerous lesion? Histological and electron microscopic aspects. J Voice. 2008;in press
  17. Martins RHG, Fabro AT, Domingues MAC, Defaver J, Silva RA. Vocal fold nodules: morphological and immuno-histochemical investigations. J Voice. 2009;in press
  18. Hsu SM, Raine L, Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled aintibody (PAP) procedure. J Histochem Cytochem. 1981;29:577–580
  19. Fuess VLR, Lorenz MC. Disfonia em professores do ensino municipal: prevalência e fatores de risco. Rev Bras Otorrinolaringol. 2003;69:807–818
  20. Thibeault SL, Merril RM, Roy N, Gray SD, Smith EM. Occupational risk factors associated with voice disorders among teachers. Ann Epidemiol. 2004;14:786–792
  21. Munier C, Kinsella R. The prevalence and impact of voice problems in primary school teachers. Occup Med. 2008;58:74–76
  22. Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg. 2000;123:385–388
  23. Richter JE. Review article: extraesophageal manifestations of gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2005;22:70–80
  24. Fang TJ, Lee LA, Li HY, Yang C, Huang CG. Helicobacter pylori colonization in the larynges of patients with hoarseness. Laryngoscope. 2008;118:389–393
  25. Cecatto SB, Costa KS, Garcia RID, Haddad L, Angélico Júnior FV, Rapoport P. Vocal cord polyps: clinical and surgical aspects. Rev Bras Otorrinolaringol. 2002;68:543–548
  26. Wallis L, Jackson-Menaldi C, Holland W, Giraldo A. Vocal fold nodule vs. vocal fold polyp: answer from surgical pathologist and voice pathologist point of view. J Voice. 2004;18:125–129
  27. Marcotullio D, Magliulo G, Pietrunti S, Suriano M. Exudative laryngeal diseases of Reinke's space: a clinicohistopathological framing. J Otolaryngol. 2002;31:376–380
  28. Wu P, Liu T, Zheng M, Chen J. Expression of vascular permeability factor in human vocal cord polyps. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006;20:839–841
  29. Gray S, Titze I. Histologic investigation of hyperphonated canine vocal cords. Ann Otol Rhinol Laryngol. 1988;97:381–389
  30. Pastuszek P, Krecicki T, Zalesska-Krecicka M, Jelen M, Rak J, Krajewska B. Histological and electron microscopic investigation of Reinke's edema. Pol J Pathol. 2003;54:61–64

 This study was financially supported by the State of São Paulo Research Foundation (FAPESP).

PII: S0892-1997(09)00068-X

doi: 10.1016/j.jvoice.2009.05.002

Journal of Voice
Volume 25, Issue 1 , Pages 98-106 , January 2011

Article Tools

* Image Usage & Resolution