Clinical Outcome of Window Partial Laryngectomy for Stage T2-3 Glottic Laryngeal Carcinoma

Wang, Shuangle; Yang, Chu; Li, Chuangwei; Lin, Xin; Yang, Dongtao; Chen, Enhe; Zeng, Yanjun

doi:10.1016/j.jvoice.2009.07.001

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Volume 25, Issue 1 , Pages 124-128, January 2011

Clinical Outcome of Window Partial Laryngectomy for Stage T2-3 Glottic Laryngeal Carcinoma

Shuangle Wang
- Department of Otorhinolaryngology Head and Neck Surgery, Shantou City Central Hospital, Shantou, China
Chu Yang
- Department of Otorhinolaryngology Head and Neck Surgery, Shantou City Central Hospital, Shantou, China
Chuangwei Li
- Department of Otorhinolaryngology Head and Neck Surgery, Shantou City Central Hospital, Shantou, China
Xin Lin
- Department of Otorhinolaryngology Head and Neck Surgery, Shantou City Central Hospital, Shantou, China
Dongtao Yang
- Department of Otorhinolaryngology Head and Neck Surgery, Shantou City Central Hospital, Shantou, China
Enhe Chen
- Department of Otorhinolaryngology Head and Neck Surgery, Shantou City Central Hospital, Shantou, China
Yanjun Zeng
- Biomechanical & Medical Information Institute, Beijing University of Technology, Ping Le Yuan, Beijing, China
- Address correspondence and reprint requests to Yanjun Zeng, Shuangle Wang, and Yanjun Zeng, Biomechanical & Medical Information Institute, Beijing University of Technology, No. 100, Ping Le Yuan, Beijing 100022, China.

Accepted 1 July 2009. published online 22 February 2010.

Summary

Objective

To investigate the operative impact and therapeutic value of window partial laryngectomy for the treatment of stage T2-3 glottic laryngeal carcinoma.

Methods

From October 2000 to December 2006, window partial laryngectomy and laryngeal reconstruction were performed on 48 appropriately selected patients with stage T2-3 glottic laryngeal carcinomas. Twenty-nine males and 19 females were included. Before the operation and in the sixth month after the operation, degree of hoarseness, vocal fold mobility and symmetry, glottal width during quiet breathing, degree of glottal closure during phonating, respiratory function, and swallowing function were surveyed. In addition, tumor recurrence and metastasis and patient survival time were monitored.

Results

With the exception of vocal fold mobility (P=0.343), there were significant differences between the two treatment groups in all areas that were investigated, including degree of hoarseness (all P<0.01), vocal fold symmetry (P=0.000), glottal width during quiet breathing (P=0.001), degree of glottal closure during phonating (P=0.001), and respiratory function (P=0.001). Swallowing function was not influenced (P=0.310). There was recurrence in one case (2.1%), cervical lymph node metastasis in one case, and hepatic metastasis in one case. The 3- and 5-year overall survival rates were 96.9% and 88.9%, respectively.

Conclusions

This study showed that window partial laryngectomy was successful for treating properly selected stage T2-3 glottic laryngeal carcinoma. This operation was effective for reducing surgical invasion and facilitated the resumption of respiratory and vocal function.

Key Words: Laryngeal neoplasms, Laryngectomy, Hoarseness, Recovery of function