Journal of Voice
Volume 25, Issue 1 , Pages e1-e6 , January 2011

Qualitative Characterization of Elastic Fiber Distribution in the Mouse Vocal Fold: Further Development of an Animal Model

This work was presented at the Voice Foundation's 38th Annual Symposium: Care of the Professional Voice; June 4, 2009; Philadelphia, Pennsylvania.

  • Christopher R. Watts

      Affiliations

    • Department of Communication Sciences & Disorders, Texas Christian University, Fort Worth, Texas
    • Corresponding Author InformationAddress correspondence and reprint requests to Christopher R. Watts, Department of Communication Sciences & Disorders, Texas Christian University, TCU Box 297450, Fort Worth, TX 76129.
  • ,
  • Jeffrey A. Marler

      Affiliations

    • Department of Otolaryngology—Head & Neck Surgery, The Ohio State University, Columbus, Ohio
  • ,
  • Bernard Rousseau

      Affiliations

    • Department of Otolaryngology, Vanderbilt University, Nashville, Tennessee

,Accepted 29 July 2009.

References 

  1. Garrett CG, Coleman JR, Reinisch L. Comparative histology and vibration of the vocal folds: implications for experimental studies in microlaryngeal surgery. Laryngoscope. 2000;110:814–824
  2. Hahn MS, Kobler JB, Starcher BC, Zeitels SM, Langer R. Quantitative and comparative studies of the vocal fold extracellular matrix I: elastic fibers and hyaluronic acid. Ann Otol Rhinol Laryngol. 2006;115:156–164
  3. Rousseau B, Hirano S, Scheidt MD, Welham NV, Thibeault SL, Chan RW, et al. Characterization of vocal fold scarring in a canine model. Laryngoscope. 2003;113:620–627
  4. Tcacencu I. Mifepristone (RU-486) impairs post-surgical wound healing of the larynx. Med Sci Monit. 2002;8:BR397–BR400
  5. Thibeault SL, Bless DM, Gray SD. Interstitial protein alterations in rabbit vocal fold with scar. J Voice. 2003;17:377–383
  6. Maunsell R, Ouaknine M, Giovanni A, Crespo A. Vibratory pattern of vocal folds under tension asymmetry. Otolaryngol Head Neck Surg. 2006;135:438–444
  7. Rousseau B, Sohn J, Montequin DW, Tateya I, Bless DM. Functional outcomes of reduced hyaluronan in acute vocal fold scar. Ann Otol Rhinol Laryngol. 2004;113:767–776
  8. Kersing W. Comparative histochemical aspects of mammalian thyroarytenoid musculature. Logoped Phoniatr Vocol. 2005;30:125–128
  9. Li DY, Brooke B, Davis EC, et al. Elastin is an essential determinant of arterial morphogenesis. Nature. 1998;393:276–280
  10. Li DY, Faury G, Taylor DG, et al. Novel arterial pathology in mice and humans hemizygous for elastin. J Clin Invest. 1998;102:1783–1787
  11. Dietz H, Mecham RP. Mouse models of genetic diseases resulting from mutations in elastic fiber proteins. Matrix Biol. 2000;19:481–488
  12. Watts CR, Marler JA, Urban Z. The effects of supravalvular aortic stenosis elastin gene mutation on voice production. J Med Speech Lang Pathol. 2007;15:395–406
  13. Gray S. Cellular physiology of the vocal folds. Otolaryngol Clin North Am. 2000;33:679–698
  14. Volic S, Klapan I, Seiwerth S, Ibrahimpasic T. Extracellular matrix of Rienke's space in some pathological conditions. Acta Otolaryngol. 2004;124:505–508
  15. Sato K. Reticular fibers in the vocal fold mucosa. Ann Otol Rhinol Laryngol. 1998;107:1023–1028
  16. Sato K, Hirano M, Nakashima T. Age-related changes of collagenous fibers in the human vocal fold mucosa. Ann Otol Rhinol Laryngol. 2002;111:15–20
  17. Fazio MJ, Mattei MG, Passage E, et al. Human elastin gene: new evidence for localization to the long arm of chromosome 7. Am J Hum Genet. 1991;48:696–703
  18. Tassabehji M, Meltcalfe K, Donnai D, Hurst J, Reardon W, Burch M, et al. Elastin: genomic structure and point mutations in patients with supravalvular aortic stenosis. Hum Mol Genet. 1997;6:1029–1036
  19. Thomas LB, Adkins JG, Andrade FH, Stemple JC. Laryngeal muscles are spared in dystrophin deficient mdx mouse. J Speech Lang Hear Res. 2008;51:586–596
  20. Titze I. Principles of Voice Production. Englewood Cliffs, NJ: Prentice-Hall; 2004;
  21. Alipour F, Berry DA, Titze IR. A finite-element model of vocal-fold vibration. J Acoust Soc Am. 2000;108:303–312
  22. Titze IR, Hunter EJ. Normal vibration frequencies of the vocal ligament. J Acoust Soc Am. 2004;115:2264–2269
  23. Hammond TH, Zhou R, Hammond EH, Pawlak A, Gray SD. The intermediate layer: a morphologic study of the elastin and hyaluronic acid constituents of normal human vocal folds. J Voice. 1997;11:59–66
  24. Gray SD, Titze IR, Alipour F, Hammond TH. Biomechanical and histologic observations of vocal fold fibrous proteins. Ann Otol Rhinol Laryngol. 2000;109:77–85
  25. Abdelkafy WM, Smith JQ, Henriquez OA, et al. Age-related changes in the murine larynx: initial validation of a mouse model. Ann Otol Rhinol Laryngol. 2007;116:618–622
  26. Portfors CV. Types and functions of ultrasonic vocalizations in laboratory rats and mice. J Am Assoc Lab Anim Sci. 2007;46:28–34
  27. Holy TE, Guo Z. Ultrasonic songs of male mice. PLoS Biol. 2005;3:2177–2186
  28. Liu RC, Miller KD. Acoustic variability and distinguishability among mouse ultrasound vocalizations. J Acoust Soc Am. 2003;114:3412–3422
  29. White NR, Prasad M, Barfield RJ, Nyby JG. 40- and 70-KHz vocalizations of mice (Mus musculus) during copulation. Physiol Behav. 1998;63:467–473
  30. Madruga de Melo EC, Lemos M, Aragão Ximenes Filho J, Sennes LU, Nascimento Saldiva PH, Tsuji DH. Distribution of collagen in the lamina propria of the human vocal fold. Laryngoscope. 2003;113:2187–2191
  31. Thomas LB, Stemple JC, Andreatta RD, Andrade FH. Establishing a new animal model for the study of laryngeal biology and disease: an anatomic study of the mouse larynx. J Speech Lang Hear Res. 2009;52:802–811

 Supported by the Jeffress Memorial Trust, grant #J-896.

 This study was performed in accordance with the Public Health Service Policy on Human Care and Use of Laboratory Animals, the National Institutes of Health Guide for the Care and Use of Laboratory Animals, and the Animal Welfare Act (7 U.S.C. et seq.); the animal protocol was approved by the Institutional Animal Care and Use Committee of James Madison University (former employer of P.I.).

PII: S0892-1997(09)00118-0

doi: 10.1016/j.jvoice.2009.07.010

Journal of Voice
Volume 25, Issue 1 , Pages e1-e6 , January 2011