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Laryngeal Granular Cell Tumor

  • Carlos Arevalo
    Affiliations
    Department of Otolaryngology/Head & Neck Surgery and Pathology, Hadassah Hebrew-University Hospital, Jerusalem, Israel
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  • Bella Maly
    Affiliations
    Department of Otolaryngology/Head & Neck Surgery and Pathology, Hadassah Hebrew-University Hospital, Jerusalem, Israel
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  • Ron Eliashar
    Affiliations
    Department of Otolaryngology/Head & Neck Surgery and Pathology, Hadassah Hebrew-University Hospital, Jerusalem, Israel
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  • Menachem Gross
    Correspondence
    Address correspondence and reprint requests to Menachem Gross, MD, Department of Otolaryngology/Head & Neck Surgery, Hadassah University Hospital, Kyriat Hadassah, P. O. Box 12000, Jerusalem 91120, Israel.
    Affiliations
    Department of Otolaryngology/Head & Neck Surgery and Pathology, Hadassah Hebrew-University Hospital, Jerusalem, Israel
    Search for articles by this author
Published:November 29, 2006DOI:https://doi.org/10.1016/j.jvoice.2006.10.003

      Summary

      Granular cell tumor (GCT) of the larynx is an uncommon, benign laryngeal neoplasm. Abrikossoff first described the tumor in 1926 as myoblastoma. The origin of this tumor has been debated in the literature. Most of the authors believe that the tumor is of neural origin due to the characteristic immunohistochemical-staining pattern. The authors describe two cases of laryngeal GCTs located in different sites with a review of the histological and clinical features, the differential diagnosis, and the treatment and the prognosis of the tumor.

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      References

        • Abrikossoff A.J.
        Uber myome.
        Virchow Arch (A). 1926; 260: 215-233
        • Eguia A.
        • Uribarri A.
        • Gay Escoda C.
        • Crovetto M.A.
        • Martinez-Conde R.
        • Aguirre J.M.
        Granular cell tumor: report of 8 intraoral cases.
        Med Oral Patol Oral Cir Bucal. 2006; 11: E425-E428
        • Victoria L.V.
        • Hoffman H.T.
        • Robinson R.A.
        Granular cell tumor of the larynx.
        J Laryngol Otol. 1998; 112: 373-376
        • Qureshi N.A.
        • Tahir M.
        • Carmichael A.R.
        Granular cell tumour of the soft tissues: a case report and literature review.
        Int Semin Surg Oncol. 2006; 3: 21
        • Sataloff R.T.
        • Ressue J.C.
        • Portell M.
        • Harris R.M.
        • Ossoff R.
        • Merati A.L.
        • Zeitels S.
        Granular cell tumors of the larynx.
        J Voice. 2000; 14: 119-134
        • Conley S.F.
        • Milbrath M.
        • Beste D.
        Pediatric laryngeal granular cell tumor.
        J Otolaryngol. 1992; 21: 450-453
        • Lazar R.H.
        • Younis R.T.
        • Kluka E.A.
        • Joyner R.E.
        • Storgion S.
        Granular cell tumor of the larynx: report of two pediatric cases.
        Ear Nose Throat J. 1992; 71: 440-443
        • Le B.H.
        • Boyer P.J.
        • Lewis J.E.
        • Kapadia S.B.
        Granular cell tumor: Immunohistochemical assessment of inhibin-alpha, protein gene product 9.5, S100 protein, CD68, and Ki-67 proliferative index with clinical correlation.
        Arch Pathol Lab Med. 2004; 128: 771-775
        • Batsakis J.G.
        Tumors of the Head and Neck.
        2nd ed. Williams & Wilkins, Baltimore, MD1997 (327–331)
        • Lassaletta L.
        • Alonso S.
        • Ballestin C.
        • Martinez-Tello F.J.
        • Alvarez-Vicent J.J.
        Immunoreactivity in granular cell tumours of the larynx.
        Auris Nasus Larynx. 1999; 26: 305-310
        • Zarovnaya E.
        • Black C.
        Distinguishing pseudoepitheliomatous hyperplasia from squamous cell carcinoma in mucosal biopsy specimens from the head and neck.
        Arch Pathol Lab Med. 2005; 129: 1032-1036
        • Kershinsnik M.
        • Batsakis J.G.
        • Makay B.
        Granular cell tumors.
        Ann Otol Rhinol Laryngol. 1994; 103: 416-419
        • Di Tommaso L.
        • Magrini E.
        • Consales A.
        • et al.
        Malignant granular cell tumor of the lateral femoral cutaneous nerve: report of a case with cytogenetic analysis.
        Hum Pathol. 2002; 33: 1237-1240