Summary
Objectives/Hypothesis
To evaluate the degree of dysplasia following cidofovir injections while documenting
human papillomavirus (HPV) type in patients with recurrent respiratory papillomatosis
(RRP).
Study Design
Retrospective chart review.
Methods
Demographic data, operative reports, and pathology results were reviewed from 25 patients
with RRP who had had cidofovir injections. All patients included had adult onset RRP,
no history of immunosuppression, well-controlled laryngopharyngeal reflux, and no
current smoking history. Eight patients were excluded because they did not meet the
inclusion criteria.
Results
Seventeen patients had adequate data for analysis and 40 subsites were identified
with sufficient data for analysis. Patients negative for both low and high risk did
not have progressive dysplasia at the conclusion of the study. Of the patients with
positive viral typing, 70% had progressive disease at the conclusion of the study.
No patients progressed to carcinoma or carcinoma in situ. The average pre- and post-treatment dysplasia scores were analyzed using a Student
paired t test. There was no difference in mean dysplasia score, indicating that there was
no increased risk of dysplasia following cidofovir treatment.
Conclusions
To our knowledge, this is the first study looking at the degree of dysplasia while
documenting HPV types in RRP. Our study suggests that HPV type appears to be relevant
in the disease progression of RRP and that cidofovir does not increase the risk of
dysplasia.
Key Words
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Article info
Publication history
Published online: October 14, 2013
Accepted:
June 28,
2013
Identification
Copyright
© 2013 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
