Summary
Objective/Hypothesis
To analyze vocal fold vibration after photofrin-mediated photodynamic therapy (PDT)
for the treatment of Tis and T1N0M0 squamous cell carcinoma (SqCCa) tumors of the
larynx. It was hypothesized that key attributes of vocal fold vibration would return
to baseline within 1–6 months of treatment.
Study Design
Retrospective.
Methods
Laryngovideostroboscopic data were retrospectively analyzed for eight patients with
Tis-T1N0M0 SqCCa tumors of the larynx treated with photofrin-mediated PDT. Baseline
and posttreatment videostroboscopy images of select vibratory characteristics of the
vocal folds were randomized and analyzed by a speech-language pathologist and fellowship-trained
laryngologist specializing in voice disorders.
Results
Significant improvement in mucosal wave (P=0.003) and amplitude of vibration (P=0.004) occurred at greater than or equal to 20 weeks post-PDT compared with baseline.
Comparing results within 5 weeks postprocedure to 10–19-weeks postprocedure revealed
significant improvement in amplitude of vibration (P=0.013) and nonvibrating portion of the vocal fold (P=0.020). Comparing results within 5-weeks postprocedure to 20 or more weeks postprocedure
revealed significant improvement in amplitude of vibration (P=0.001), mucosal wave (P=0.001), and nonvibrating portion of the effected fold (P=0.001).
Conclusion
Photofrin-mediated PDT allows for preservation of function and structure of the larynx
without systemic toxicity; however, it may take 4–5 months or more for key vibratory
characteristics of the vocal folds to recover posttreatment.
Key Words
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Article info
Publication history
Published online: October 10, 2013
Accepted:
July 25,
2013
Identification
Copyright
© 2013 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
