Summary
Objectives
The objective of this study was to measure the elastic modulus (Young's modulus) of
canine vocal fold cover layers.
Study Design
Basic science study.
Methods
Cover layers from vocal folds of eight canine larynges were dissected. Cover layer
samples from the mid-membranous, medial vocal fold surface area were used to measure
material stiffness using a previously validated indentation method. Cover layers from
two human larynges were also measured as control references. Superior and inferior
medial cover layers were measured separately. A total of 15 superior medial surface
and 17 inferior medial surface specimens from the canine and two and four specimens,
respectively, from the human were tested.
Results
In the canine larynges, the mean Young's modulus of the superior medial surface was
4.2 kPa (range, 3.0–5.4 kPa; standard deviation [SD], 0.6 kPa) and of the inferior
medial surface was 6.8 kPa (range, 5.4–8.5 kPa; SD, 0.8 kPa). Measurements on human
cover samples were 5.0 kPa (range, 4.7–5.4 kPa; SD, 0.5 kPa) and 7.0 kPa (range, 6.7–7.3
kPa; SD, 0.3 kPa) for the superior medial and inferior medial surface, respectively.
Human measurements were similar to the previously validated measurements. There was
no difference between the stiffness measurements in the human and canine cover layer
samples (P > 0.05).
Conclusions
The elastic stiffness (Young's modulus) of the canine and human vocal fold cover layers
is similar. Findings support the use of canine larynx as an externally valid model
to study voice production.
Key Words
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Article info
Publication history
Published online: February 03, 2014
Accepted:
December 4,
2013
Footnotes
Financial Disclosure: This study was supported by grant no. RO1DC011300 from the National Institutes of Health.
Conflict of Interest: None.
Identification
Copyright
© 2014 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
