Fundamental Frequency of Crying in Two-month-old Boys and Girls: Do Sex Hormones During Mini-puberty Mediate Differences?

  • Anja Borysiak
    Affiliations
    Center for Pre-Speech Development and Developmental Disorders, Department of Orthodontics, University of Würzburg, Würzburg, Germany
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  • Volker Hesse
    Affiliations
    German Center for Growth, Development and Health Encouragement during Childhood and Youth, Children's Hospital Berlin-Lindenhof, Germany

    Institute for Experimental Paediatric Endocrinology, Charité – University Medicine, Berlin, Germany
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  • Peter Wermke
    Affiliations
    Center for Pre-Speech Development and Developmental Disorders, Department of Orthodontics, University of Würzburg, Würzburg, Germany

    IT Center, University of Würzburg, Germany
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  • Johannes Hain
    Affiliations
    Department of Mathematics (Statistics), University of Würzburg, Germany
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  • Michael Robb
    Affiliations
    School of Health Sciences, University of Canterbury, Christchurch, New Zealand.
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  • Kathleen Wermke
    Correspondence
    Address correspondence and reprint requests to Kathleen Wermke, Center for Pre-Speech Development and Developmental Disorders, University Clinics, Julius-Maximilians-University of Würzburg, 97070 Würzburg, Germany.
    Affiliations
    Center for Pre-Speech Development and Developmental Disorders, Department of Orthodontics, University of Würzburg, Würzburg, Germany
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Published:January 14, 2016DOI:https://doi.org/10.1016/j.jvoice.2015.12.006

      Summary

      Objective

      To evaluate whether the puberty-like sex hormone surge during the first months of life (mini-puberty) affects fundamental frequency (fo) in infant crying as one would derive from hormone influences on voice in adults.

      Study Design

      Populational prospective study.

      Participants

      Twenty healthy normal-hearing infants (nine boys) were recruited for participation.

      Methods

      Spontaneously uttered cries were collected from each infant at 8 weeks of age. The cries were acoustically analyzed for mean fo and fo range. The fo properties were correlated to the average serum levels of bioavailable estradiol (E2) (mean E2/sex hormone-binding globulin [SHBG]) and testosterone (T) (mean T/SHBG) across the second month of life.

      Results

      Whereas no significant hormone effect was found for mean fo, a significant negative correlation (r = −0.55) was found between fo range and mean E2/SHBG. No indication for a T influence on fo features was found at this age. Although girls showed a slightly higher mean E2 concentration than boys did, the observed differences in cry fo range were judged to be reflective of an infant's serum concentration of E2 rather than a sex-based difference.

      Conclusion

      In the absence of laryngeal size differences between female and male infants, the result was interpreted as indicative of an E2 influence on viscoelastic properties of the vocal folds. In our opinion, the investigation of young infants' vocalizations during the early postnatal surge of sex steroids (mini-puberty) may advance our understanding of the mechanisms mediating average sex differences in vocal development and early communication.

      Key Words

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