Summary
Background
Patients with human papillomavirus (HPV) DNA–positive recurrent laryngeal papillomatosis
commonly have repeated recurrences following surgery. The reason is suspected to be
a mechanism by which latent HPV infection in the surrounding healthy mucosa reinfects
the surgical site. It may be that production of HPV antibodies in the laryngeal mucosa
with Gardasil injection could inhibit postoperative recurrence.
Study Design
This is a case series study.
Purpose
The purpose of this study was to examine whether Gardasil injection effectively inhibits
recurrence. However, as a first report, we describe the antibody titers before and
after vaccination.
Methods
Gardasil was injected in 12 men (aged 32–74 years; mean age 47.9 years) with HPV-positive
laryngeal papillomatosis. Serum antibody titers of HPV-6, -11, -16, and -18 were measured
by a competitive Luminex-based immunoassay before the vaccination and 7 months after
the start of the vaccination.
Results
Each of the antibody titers was very low before vaccination, and they rose in all
patients after the vaccination.
Conclusions
This finding demonstrates that antibody titers increase with Gardasil injection in
post-adolescent males.
Key Words
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Article info
Publication history
Published online: April 08, 2016
Accepted:
January 20,
2016
Footnotes
Presented at the Annual Meeting of the American Academy of Otolaryngology—Head and Neck Surgery, Dallas, TX, September 27–30, 2015.
Identification
Copyright
© 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
