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Gardasil Vaccination for Recurrent Laryngeal Papillomatosis in Adult Men

First Report: Changes in HPV Antibody Titer

      Summary

      Background

      Patients with human papillomavirus (HPV) DNA–positive recurrent laryngeal papillomatosis commonly have repeated recurrences following surgery. The reason is suspected to be a mechanism by which latent HPV infection in the surrounding healthy mucosa reinfects the surgical site. It may be that production of HPV antibodies in the laryngeal mucosa with Gardasil injection could inhibit postoperative recurrence.

      Study Design

      This is a case series study.

      Purpose

      The purpose of this study was to examine whether Gardasil injection effectively inhibits recurrence. However, as a first report, we describe the antibody titers before and after vaccination.

      Methods

      Gardasil was injected in 12 men (aged 32–74 years; mean age 47.9 years) with HPV-positive laryngeal papillomatosis. Serum antibody titers of HPV-6, -11, -16, and -18 were measured by a competitive Luminex-based immunoassay before the vaccination and 7 months after the start of the vaccination.

      Results

      Each of the antibody titers was very low before vaccination, and they rose in all patients after the vaccination.

      Conclusions

      This finding demonstrates that antibody titers increase with Gardasil injection in post-adolescent males.

      Key Words

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