Summary
Objective
The aim of our study was to clarify the human papillomavirus (HPV) infection status
of various laryngeal diseases in Tokyo, Japan.
Study Design
This is a retrospective study.
Methods
A total of 144 patients who underwent surgical resection for various laryngeal lesions
were enrolled in this study. These subjects were categorized into four groups based
on lesion type: non-neoplastic, 44; precancerous, 29; cancer, 35; and papilloma, 36.
To determine the rate of HPV infection, laryngeal secretions and resected tissue from
our study participants were examined by liquid-phase hybridization (LPH) and consensus
primer-directed polymerase chain reaction (PCR).
Results
The LPH for low-risk HPV was applied to all 144 patients, and that for high-risk HPV
was additionally applied to 121 of the 144 patients. The PCR was applied to 94 of
the 144 patients. The LPH detected low-risk HPV-DNA in 23 patients (1 cancer and 22
papillomas) and high-risk HPV-DNA in 3 patients (1 cancer and 2 papillomas). The PCR
detected HPV-6 and HPV-11 in the papilloma group, whereas it detected HPV-31 in one
patient with laryngeal cancer and one patient with precancerous lesion. Both the LPH
and the PCR revealed the HPV infection rate in the non-neoplastic group to be 0%.
Conclusions
Although we found no significant difference in the HPV-DNA positive rates of laryngeal
cancer and precancerous lesions in the non-neoplastic group, the positive rates were
significantly smaller in this group than in the papilloma group. In the Tokyo area,
HPV had little or no association with laryngeal cancer, precancerous lesions, and
non-neoplastic lesions in the larynx.
Key Words
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Article info
Publication history
Published online: December 13, 2016
Accepted:
November 16,
2016
Identification
Copyright
© 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
