Summary
Hyaluronidase (HAase) injection into the vocal folds is an off-label use of an enzyme
for liquefaction of hyaluronic acid (HA). HAase injection was performed in 14 cases
in 13 patients. Office and operative injections of HAase were performed. The indications
were five cases of overinjection of HA, six cases of Reinke edema and polypoid corditis,
and three cases of acute vocal hemorrhage with early fusiform polyp formation. All
the patients tolerated the HAase without complications. Significant voice improvements
were noted between pre- and postinjection procedures as evaluated by a self-rating
of voice by the Voice Handicap Index-10. A marked decrement in the mass on the side
of the injection of HAase was noted in all groups successfully injected upon viewing
by videostroboscopy. HAase prevented an additional operative phonosurgery in 10 patients.
In conclusion, HAase injection can be used in the vocal folds with good effect in
patients. The indications are polypoid corditis with overproduction of HA, acute vocal
hemorrhage, and correction of iatrogenic HA overinjection.
Key Words
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Article info
Publication history
Published online: September 01, 2017
Accepted:
July 5,
2017
Footnotes
Presented at The Voice Foundation Annual Meeting May 31–June 7, 2017, Philadelphia, PA.
Identification
Copyright
© 2018 Published by Elsevier Inc. on behalf of The Voice Foundation.
