Summary
Objective
The aim of this study was to investigate the effects of intracordal estradiol and
dexamethasone injection on wound healing in vocal fold injuries.
Study Design
A prospective controlled animal study was carried out.
Setting
This study was conducted at a tertiary center.
Subjects-Methods
Ten rabbits were randomly divided into two groups. As surgical procedure, cordotomy
technique was performed in the middle third of the vocal folds bilaterally. In the
first group, 0.1 mL of dexamethasone was injected into the right side, and 0.1 mL
of saline was injected into the left side. In the second group, 0.1 mL of estradiol
was injected into the right side, and 0.1 mL of saline was injected into the left
side. Animals were sacrificed after 1 month and laryngeal specimens were evaluated
histopathologically.
Results
No statistically significant difference was observed in terms of inflammatory response,
epithelial thickness, type I and III collagen, and hyaluronic acid parameters in dexamethasone
and estradiol injections compared to the saline injection. In terms of elastin level,
estradiol injection demonstrated statistically higher values compared to the saline
injection. Elastin level of dexamethasone injected vocal folds was not statistically
different compared to the saline injection. No significant differences were observed
in terms of inflammatory response, epithelial thickness, type I and III collagen,
and hyaluronic acid parameters between the estradiol and dexamethasone injected vocal
folds.
Conclusion
It is thought that the effects of estradiol or dexamethasone injections may have similar
effects on wound healing in vocal fold injuries. Intracordal estradiol injection has
positive effects on tissue elastin levels.
Key Words
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Article info
Publication history
Published online: February 26, 2018
Accepted:
January 23,
2018
Footnotes
This article was presented at the 38th National Otolaryngology Congress, October 26–30, 2016, Antalya, Turkey, and won the first prize.
Identification
Copyright
© 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
