Summary
Purpose
In this study, we attempted to assess the phonation and articulation subsystem changes
in patients with multiple sclerosis compared to healthy individuals using Dysphonia
Severity Index and Formant Centralization Ratio with the aim of evaluating the correlation
between these two indexes with neurological status.
Materials and Methods
A sample of 47 patients with multiple sclerosis and 20 healthy speakers were evaluated.
Patients’ disease duration and disability were monitored by a neurologist. Dysphonia
Severity Index and Formant Centralization Ratio scores were computed for each individual.
Acoustic analysis was performed by Praat software; the statistical analysis was run
using SPSS 21. To compare multiple sclerosis patients with the control group, Mann-Whitney
U test was used for non-normal data and independent-samples t test for normal data. Also a logistic regression was used to compare the data. Correlation
between acoustic characteristics and neurological status was verified using Spearman
correlation coefficient and linear regression was performed to evaluate the simultaneous
effects of neurological data.
Results
Statistical analysis revealed that a significant difference existed between multiple
sclerosis and healthy participants. Formant Centralization Ratio had a significant
correlation with disease severity.
Conclusion
Multiple sclerosis patients would be differentiated from healthy individuals by their
phonation and articulatory features. Scores of these two indexes can be considered
as appropriate criteria for onset of the speech problems in multiple sclerosis. Also,
articulation subsystem changes might be useful signs for the progression of the disease.
Keywords
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References
- Acoustic analysis of dysarthria associated with multiple sclerosis.Clin Linguist Phon. 1995; 9: 95-120
- Lip and tongue function in multiple sclerosis: a physiological analysis.Motor Control. Apr. 1998; 2: 148-160
- Predicting early bulbar decline in amyotrophic lateral sclerosis: a speech subsystem approach.Behav Neuro. 2015; 2015
- Expressive communication disorders in persons with multiple sclerosis: a survey.Arch Phys Med Rehabil. 1985; 66: 675-677
- Formant centralization ratio: a proposal for a new acoustic measure of dysarthric speech.J Speech Lang Hear Res. 2010; 53: 114-125
- Dysarthria in multiple sclerosis.J Speech Lang Hear Res. 1972; 15: 229-245
- Clinical analysis methods of voice disorders.Curr Bioinform. 2011; 6: 270-285
- Acoustic studies of dysarthric speech: Methods, progress, and potential.J Commun Disord. 1999; 32: 141-186
- Impairment of vowel articulation as a possible marker of disease progression in Parkinson's disease.PLoS One. 2012; 7: e32132
- Characteristics of motor speech phenotypes in multiple sclerosis.Mult Scler Relat Disord. 2018; 19: 62-69
- Acoustic analysis of voice in multiple sclerosis patients.J Voice. 2004; 18: 341-347
- Objective and subjective evaluation of voice quality in multiple sclerosis.J Voice. 2007; 21: 735-740
- Comparability of perceptual analysis of speech characteristics in Australian and Swedish speakers with multiple sclerosis.Folia Phoniatr Logop. 2003; 55: 177-188
- Correlation of the Dysphonia Severity Index (DSI), Consensus Auditory-Perceptual Evaluation of Voice (CAPE-V), and gender in Brazilians with and without voice disorders.J Voice. 1 Nov. 2016; 30: 765.e7-765.e11
- The dysphonia severity indexan objective measure of vocal quality based on a multiparameter approach.J Speech Lang Hear Res. 2000; 43: 796-809
- Outcome of laryngeal manual therapy in four Dutch adults with persistent moderate-to-severe vocal hyperfunction: a pilot study.J Voice. 2004; 18: 467-474
- The relationship between perceptual evaluation and objective multiparametric evaluation of dysphonia severity.J Voice. 2008; 22: 138-145
- Measuring the Dysphonia Severity Index (DSI) in the Program Praat.J Voice. 2017; 31: 644.e29-644.e40
- Observation of the dysphonia severity index in evaluating curative effect of vocal cord polyp surgery.Zhonghua er bi yan hou tou jing wai ke za zhi= Chin J Otorhinolaryngol Head Neck Surg. 2015; 50: 673-676
- The applicability of the dysphonia severity index and the voice handicap index in evaluating effects of voice therapy and phonosurgery.J Voice. 2010; 24: 199-205
- Influence of age and gender on the Dysphonia Severity Index.Folia Phoniatr Logop. 2006; 58: 264-273
- Effects of intensive voice treatment (LSVT®) on vowel articulation in dysarthric individuals with idiopathic Parkinson disease: acoustic and perceptual findings.J Speech Lang Hear Res. 2007; 50: 899-912
- Imprecise vowel articulation as a potential early marker of Parkinson's disease: effect of speaking task.J Acoust Soc Am. 2013; 134: 2171-2181
- Acoustic characteristics of American English vowels.J Acoust Soc Am. 1995; 97: 3099-3111
- Vowel posture normalization.J Acoust Soc Am. 1998; 104: 2426-2437
- Vocal symptoms and acoustic changes in relation to the expanded disability status scale, duration and stage of disease in patients with multiple sclerosis.Eur Arch Otorhinolaryngol. 2009; 266: 1759-1765
- Subjective and perceptual analysis of voice quality and relationship with neurological disfunction in multiple sclerosis patients.Clin Neurol Neurosurg. 2013; 115: S17-S20
- Multiple sclerosis epidemiology in East Asia, South East Asia and South Asia: a systematic review.Neuroepidemiology. 2016; 46: 209-221
- Rating neurologic impairment in multiple sclerosis an expanded disability status scale (EDSS).Neurology. 1983; 33: 1444-1452
- Objective and subjective evaluation of voice quality in multiple sclerosis.J Voice. 2007; 21: 735-740
- Comparison of acoustic features of high-low vowels with perceptual speech intelligibility in normal and adults with Parkinson.Jundishapur Sci Med J. 2013; 12: 385-392
- Multiple sclerosis: associated speech and language disorders.Aust J Hum Commun Disord. 1987; 15: 15-35
- The existence of phonatory instability in multiple sclerosis: an acoustic and electroglottographic study.Neurol Sci. 2010; 31: 259-268
- A comparison of Dysphonia Severity Index in female teachers with and without voice complaints in elementary schools of Tehran, Iran.Nurs Midwifery Stud. 2013; 1: 133-138
- Characteristics of multiple sclerosis as a function of the severity of speech disorders.J Med Speech Lang Pathol. 1 Jun. 2003; 11: 73-85
- Acoustic and intelligibility characteristics of sentence production in neurogenic speech disorders.Folia Phoniatr Logop. 2001; 53: 1-18
Article info
Publication history
Published online: October 17, 2018
Accepted:
September 24,
2018
Footnotes
The data for this research article were derived from the MSc thesis of a student of Ahvaz Jundishapur University of Medical Sciences. Thesis funding was provided by Ahvaz Jundishapur University of Medical Sciences. (Master Thesis grant no: pht-9517).
Identification
Copyright
© 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
