Summary
Introduction
Some studies have demonstrated that the intrinsic muscles of the larynx show no signs
of damage to the muscle fiber and raise a possibility of preservation of the laryngeal
muscles in muscular dystrophies. A cross-sectional study was implemented with a case
series of patients with Duchenne muscular dystrophy.
Methods
This study was carried out through a medical assessment through anamnesis and medical
records, perceptual-auditory evaluation of the voice in 15 patients, and videolaryngoscopic
evaluation in 11 patients.
Results
All patients had the maximum phonation time of the vowel /e/ decreased, 7 (46.7%)
had reduced loudness while 10 (66.7%) had vocal asthenia. There were no changes in
muscular tone and mobility in the videolaryngoscopy.
Discussion
Patients with Duchene muscular dystrophy do not present abnormalities suggestive of
the involvement of the intrinsic muscles of the larynx but have vocal worsening due
to pulmonary impairment.
Key Words
Abbreviations:
BIPAP (Bilevel Positive Airway Pressure), BMD (Becker Muscular Dystrophy), CAAE (Certificate of Presentation for Ethical Appreciation), DMD (Duchenne Muscular Dystrophy), GRBASI (scale, roughness (G), hoarseness (R), breathiness (B), asthenia (A), tension (S) and vocal instability (I)), MPT (The Maximum Phonation Time), PMD (Progressive Muscular dystrophy), SMD (Steinert Muscular Dystrophy)To read this article in full you will need to make a payment
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REFERENCES
- Tratado de neurologia.12ª ed. Guanabara Koogan, Rio de Janeiro2011
- Aminoglycoside-induced mutation suppression (stop codon readthrough) as a therapeutic strategy for Duchenne muscular dystrophy.Ther Adv Neurol Disord. 2010; 3: 379‐389
- Functional and Clinical Profile of Duchenne muscular dystrophy patients attending the Brazilian Association of muscular dystrophy (ABDIM).Rev Neuroscience. 2006; 14: 015-022
- Distrofia muscular de Becker. Relato de caso e revisão de literatura.Rev Acta Fisiátrica. 1996; 3: 18-23
- False vocal fold characteristics in presbylarynges and recurrent laryngeal neuropathy.Ann Otol Rhinol Laryngol. 2017; 126: 42-46
- Quantitative analysis of videostroboscopic images in presbylarynges.Laryngoscope. 2001; 111: 2022-2027
- nia in the aging: physiology versus disease.Laryngoscope. 1992; 102: 139-144
- Características Glóticas de Presbilaringe: Relação Com Queixa Vocal e Alterações de Mucosa Das Pregas Vocais [Tese].Universidade Federal de São Paulo (UNIFESP), São Paulo2000: 112 ([s.n.])
- Intrinsic Laryngeal Muscle Sparing in mdx Mice.Muscle Nerve. 2007; 35: 349-353
- Intrinsic laryngeal muscles are spared from degeneration in the dy3k/dy3k mouse model of congenital muscular dystrophy type 1a.Muscle Nerve. 2009; 39: 91-94
- Changes in calsequestrin, TNF-a, TGF-b and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles.Int. J. Exp. Pathol. 2015 Oct; 96: 285-293
- Age-related changes in dystrophin-glycoprotein complex and in utrophin are not correlated with intrinsic laryngeal muscle protection in mdx mice.Muscle Nerve. 2011; 4: 978-980
- Determination of the normal thresholds of the acoustic parameters of the voice.Interunidades em Bioengenharia, University of São Paulo, São Carlos2003
- Correlação entre dados perceptivo-auditivos e qualidade de vida em voz de idosas.Pró-Fono Revista de Atualização Científica. 2009; 21: 125-130
- Clinical examination of voice.Springer Verlag, New York1981: 81-84
- Tempo máximo fonatório de /e/ e /ė/ não-vozeado e sua relação com índice de massa corporal e sexo em crianças.Rev CEFAC. 2016; 18 (Available at:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-18462016000200491&lng=en&nrm=iso. Accessed April 1, 2020): 491-497
- Survival in Duchenne muscular dystrophy.Acta Myol. 2012; 31: 117-120
- Relação do pico de fluxo expiratório com o tempo de fonação em pacientes asmáticos.Rev CEFAC. 2006; 8 (Available a:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S151618462006000400012&lng=en&nrm=iso. Accessed April 1, 2020): 509-517
- Disfonias: relação S/Z e tipos de voz.Rev CEFAC. 2008; 10 (Available at:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S151618462008000400014&lng=en&nrm=iso. Accessed April 1, 2020): 536-547
Article Info
Publication History
Published online: September 17, 2020
Accepted:
August 25,
2020
Footnotes
Ethical Publication Statement: We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.
None of the authors has any conflict of interest to disclose.
Identification
Copyright
© 2020 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
