Summary
Purpose
Laryngeal dystonia is a chronic neurologic disorder characterized by intention-induced
spasms of the vocal folds driven by aberrant central motor processing. The use of
in-office transcervical botulinum toxin injection for the treatment of laryngeal disorders,
such as laryngeal dystonia, has been deemed safe and efficacious. There is, however,
no available data outlining the hemodynamic changes experienced by patients undergoing
this frequently performed procedure.
Methods
One hundred and one patients diagnosed with laryngeal dystonia were enrolled in this
prospective study. These patients underwent transcervical laryngeal botulinum toxin
injection to address their dysphonia. Vital signs where acquired prior to, and at
the time of injection. Alterations in these parameters were then evaluated for statistical
significance.
Results
Statistically significant increases in mean heart rate (5.8 ± 10.8 bpm, P < 0.0001), systolic blood pressure and diastolic blood pressure (7.0 ± 9.5 mm Hg,
P < 0.0001; 8.7 ± 14.7 mm Hg, P < 0.0001) were discovered. No statistically significant difference in oxygen saturation
was noted and no patients in the study faced major adverse outcomes.
Conclusions
Though these findings may not have related to clinically significant complication,
our study demonstrates the importance of understanding potential stressors in a procedure
routinely performed by laryngologists. This may result in more careful patient selection,
alterations in procedure, and improved safety by acting in a timely fashion if alarming
changes in hemodynamic parameters are noted.
Key Words
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Article info
Publication history
Published online: February 01, 2021
Accepted:
January 18,
2021
Footnotes
Funding: The authors woud like to aknowledge the use of services provided by the Wake Forest Clinical and Translational Science Institute (WFCTSI) National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, through Grant Award Number UL1TR001420
Conflict of Interest and Financial Disclosures: None.
Identification
Copyright
© 2021 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
