Summary
Objectives
Expression of mu-opioid receptors (MORs) has not been investigated in head and neck
cancer. In this study, we aimed to assess the expression of opioids receptors in laryngeal
cancer, compared to adjacent non-malignant tissue.
Study design
A retrospective case series in a single academic center.
Methods
Sixty-four specimens were taken from 32 matched patients, diagnosed with laryngeal-carcinoma
(20 supraglottic and 12 glottic), and were analyzed using immunohistochemical stains
for MOR. All sections were examined and evaluated with a semi-quantitative analysis
for staining intensity and cell count for a percentage of the positively stained cells.
Survival of patients was compared based on MOR expression.
Results
MOR staining intensity was significantly increased in laryngeal-carcinoma compared
to the normal tissue adjacent to the carcinoma (P = 0.019). The percentage of stained cells in non-involved supraglottis was significantly
higher compared to the non-involved glottis (P = 0.022), yet this difference was no longer found between supra- and glottic-carcinoma
tissues.
Conclusion
MOR may play a role in the laryngeal cancer environment, as the expression in tumor
cells alters from adjacent non-cancerous tissue.
Key Words
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Article info
Publication history
Published online: March 07, 2021
Accepted:
February 11,
2021
Footnotes
Funding: None
Identification
Copyright
© 2021 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
