Summary
Objective
Reinke's edema is a benign laryngeal disease characterized by inflammation and swelling
of the superficial layer of the lamina propria of the vocal fold, known as Reinke's
space. The aim of this study was to evaluate the quality of voice by quantitative
acoustic measurements in patients affected by RE according to new classification proposed
by de Vincentiis.
Study Design
Prospective case-control.
Methods
We enrolled 76 consecutive patients with RE: eight type 1, 36 type 2, four type 3.
and 28 type 4. A population of 30 healthy subjects was enrolled too. A voice recording
for each subject was performed and the analysis were performed using the Multi-Dimensional
Voice Program. The parameters considered were: fundamental frequency (F0), Jitter%
(Jitt%), Shimmer% (Shim%), and Noise Harmonics to Ratio (NHR). Statistical analyses
were performed using GraphPad Prism 8 software. A level of significance of P < 0.05 was used.
Results
The mean values and standard deviation for each parameter for the male group of patients
affected by RE are: F0 101.06 (± 9.56) Hz, Jitt% 2.254 (±0.93), Shim% 9,037 (±2.21)
and NHR 0.235 (±0.099). About the female group, the mean values are: F0 147,58 (±13.68)
Hz, Jitt% 3,733 (±1.12), Shim% 11.172 (±3.54) and NHR 0.278 (±0.12). The difference
between the types of RE and reference sample people in male and female groups are
statistically significative (P < 0.05) for each parameter. In the female group all outcomes are statistically different
except the F0 and NHR between healthy people and type III RE patients.
Conclusions
RE is one of the most common diseases of true vocal folds and the classification proposed
by de Vincentiis is a synthesis of endoscopic findings. In this paper we underline
the change in vocal quality before surgery according a new type of RE classification.
Key Words
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REFERENCES
- Reinke's Edema.Otolaryngol Clin North Am. 2019; 52: 627-635https://doi.org/10.1016/j.otc.2019.03.006
- Clinical grading of Reinke's edema.Laryngoscope. 2017; 127: 2310-2313https://doi.org/10.1002/lary.26647
- Association between laryngopharyngeal reflux and benign vocal folds lesions: a systematic review.Laryngoscope. 2019; 129: E329-E341https://doi.org/10.1002/lary.27932
- Voice analysis of patients with diverse types of Reinke's edema and clinical use of electroglottographic measurements.Acta Otolaryngol. 2006; 126: 62-69https://doi.org/10.1080/00016480510043927
- A clinical study of Reinke's edema.Auris Nasus Larynx. 1988; 15: 57-78https://doi.org/10.1016/s0385-8146(88)80010-5
- Morphologische Klassifikation des Reinke-Odems mittels optischer Kohärenztomografie [Morphologic classification of Reinke's edema through optical coherence tomography].Laryngorhinootologie. 2010; 89: 224-227https://doi.org/10.1055/s-0029-1243169
- Reinke's edema: a proposal for a classification based on morphological characteristics.Eur Arch Otorhinolaryngol. 2020; 277: 2279-2283https://doi.org/10.1007/s00405-020-05934-8
- Acoustic parameters for the evaluation of voice quality in patients with voice disorders.Ann Palliat Med. 2021; 10: 130-136https://doi.org/10.21037/apm-20-2102
- Is Reinke's edema a precancerous lesion? Histological and electron microscopic aspects.J Voice. 2009; 23: 721-725https://doi.org/10.1016/j.jvoice.2008.03.001
- Reinke's oedema: a premalignant condition?.J Laryngol Otol. 1986; 100: 1159-1162https://doi.org/10.1017/s0022215100100751
- Long-term follow-up study of laryngeal precancer.Auris Nasus Larynx. 1998; 25: 407-412https://doi.org/10.1016/s0385-8146(98)00041-8
- Does Reinke's edema grade determine premalignant potential?.Ann Otol Rhinol Laryngol. 2018; 127: 812-816https://doi.org/10.1177/0003489418796529
- Gender and age in benign vocal fold lesions.Laryngoscope. 2015; 125: 191-196https://doi.org/10.1002/lary.24911
- A clinico-pathological study of Reinke'S oedema.Indian J Otolaryngol Head Neck Surg. 2003; 55: 160-165https://doi.org/10.1007/BF02991943
- Management of common voice problems: Committee report.Otolaryngol Head Neck Surg. 2002; 126: 333-348https://doi.org/10.1067/mhn.2002.123546
- Determination of fundamental frequency and voice intensity in Iranian men and women aged between 18 and 45 years.J Voice. 2012; 26: 336-340https://doi.org/10.1016/j.jvoice.2011.05.008
- Deviant vocal fold vibration as observed during videokymography: the effect on voice quality.J Voice. 2001; 15: 313-322https://doi.org/10.1016/S0892-1997(01)00033-9
- Vibratory source, vocal quality and fundamental frequency following pediatric laryngotracheal reconstruction.Int J Pediatr Otorhinolaryngol. 2007; 71: 1261-1269https://doi.org/10.1016/j.ijporl.2007.04.018
- Vocal-fold vibration of patients with Reinke's edema observed using high-speed digital imaging.Auris Nasus Larynx. 2016; 43: 654-657https://doi.org/10.1016/j.anl.2016.02.007
Article info
Publication history
Published online: June 08, 2022
Accepted:
May 12,
2022
Publication stage
In Press Corrected ProofFootnotes
The authors received no financial support for the research, authorship, and/or publication of this article.
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
