Summary
Objective
This systematic review and meta-analysis seeks to characterize the rate of malignant
progression among patients with laryngeal dysplasia treated with photoangiolytic laser
and compare to prior systematic reviews of conventional surgical approaches.
Methods
OVIDMedline, Pubmed, Cumulative Index to Nursing and Allied Health Literature (CINAHL),
and Google Scholar were searched, including terms related to patients with vocal fold
dysplasia who were treated by angiolytic laser ablation. Some articles already known
to authors or identified through hand searching were included.
Results
Six articles with 155 cases were included. Two studies used potassium titanyl phosphate exclusively,
one solely used the pulsed dye laser, and three studies utilized both laser types
during the study period. The pooled overall mean of malignant progression for patients
with laryngeal dysplasia treated with photoangiolytic laser was 12%, as calculated
by conducting a meta-analysis of single arm proportion.
Conclusion
Laryngeal dysplasia is a premalignant lesion which confers a risk of progression to
malignancy. After biopsy to establish the diagnosis there are multiple surgical techniques
available for treatment with the goal of lesion eradication and voice preservation.
In our review, there is a low malignant transformation rate for patients treated via
with photoangiolytic laser.
Key Words
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Article info
Publication history
Published online: July 15, 2022
Accepted:
June 14,
2022
Publication stage
In Press Corrected ProofFootnotes
Funding source: none.
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
