Summary
Objective
Casting more information on the link between GERD and LPR by investigating the prevalence
of laryngopharyngeal symptoms in patients with severe GERD refractory to medical treatment.
Design
Prospective Study
Methods
Fifty patients with typical GERD symptoms presenting for EGD were recruited. All patients
filled the GERD-Health-Related Quality of Life (HRQL) questionnaire and were screened
for LPR using the Reflux Symptom Score questionnaire. All patients were also evaluated
for the presence of hiatal hernia, esophagitis, inlet patch, gastritis (erosive vs.
non erosive), polyps, intestinal metaplasia and or Helicobacter pylori infection.
Laryngeal images were taken during EGD and evaluated using the Reflux Sign Assessment
(RSA).
Results
A total of 50 patients were recruited for this study. The prevalence of heartburn
was the highest (90%). The mean score of GERD-HRQL was 30.76±15.09. The mean RSS score
was 70.96±46.08. Laryngeal examination was documented in 49 patients. the most common
finding was edema (34.7%) followed by redness (28.6%). The mean RSA score for the
total group was 21.15±8.04. There was a strong correlation between RSS score and GERD-HQRL
score. There was no significant correlation between the RSS and any of the EGD findings
(P > 0.05). There was no significant correlation between RSA and GERD-HRQL scores or
any of the EGD findings (P > 0.05). However, there was a significant correlation between total RSA and RSS scores
(rho=0.287, P = 0.04).
Conclusion
The suggested high prevalence of LPRD should alarm the treating physician to the need
for a thorough otolaryngologic examination in patients presenting with severe GERD,
particularly those in whom the LPR symptoms may be masked by the typical symptoms
of GERD.
Key Words
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Article info
Publication history
Published online: July 16, 2022
Accepted:
June 16,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
