Investigation of Reflux Characteristics in Outpatients of Otorhinolaryngology-Head and Neck Surgery by Age and Gender in the Chinese Population

  • Xiaoyu Wang
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, 230032, Anhui Province, China
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  • Jinhong Zhang
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, 100048
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  • Zhi Liu
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, 100048
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  • Chun Zhang
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, 100048
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  • Shizhen Zou
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, 100048
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  • Jinrang Li
    Address correspondence and reprint requests to Dr. Jinrang Li, Anhui Medical University, Department of Otolaryngology, Sixth Medical Center of PLA General Hospital, Beijing 100048, China, Phone: 18600310277
    Department of Otolaryngology, Sixth Medical Center of PLA General Hospital, Anhui Medical University, Beijing 100048, China
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      To investigate the characteristics of patients with reflux diseases in the otorhinolaryngology-head and neck surgery clinics through the Reflux Symptom Scale-12 (RSS-12) and the Gastroesophageal Reflux Disease Questionnaire (GERD-Q).


      All included patients completed the RSS-12 and GERD-Q scales and were considered to have LPR with an RSS-12 score >11 and GERD with a GERD-Q score >7. Data were analyzed according to genders (male and female) and age (18-40, 41-60, and >60 years).


      A total of 977 patients were included. the mean RSS-12 and GERD-Q score were 11.32±21.34 and 6.31±1.21, and the positive rate of LPR and GERD were 28.76% and 8.90%, respectively. Males had a higher positive rate of LPR and GERD than females, and there were more males with LPR who also had GERD. Among those with both LPR and GERD, males had significantly higher ear-nose-throat (ENT) symptom scores such as hoarseness and excess throat mucus than females. However, females had significantly higher scores of gastrointestinal (GI) symptoms, mainly indigestion and abdominal pain, and elder patients (>60 years) had higher scores of ENT, GI, respiratory symptoms, as well as the impact of symptoms on quality of life than the young patients (18-40, and 41-60 years).


      Patients in the otorhinolaryngology-head and neck surgery clinics have different reflux characteristics by gender and age in the Chinese population. Males had more severe ENT-related symptoms of distress, while females had more complaints of GI symptoms. Older patients had higher scores for ENT, GI and respiratory symptoms.

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