Summary
Objective
To investigate the characteristics of patients with reflux diseases in the otorhinolaryngology-head
and neck surgery clinics through the Reflux Symptom Scale-12 (RSS-12) and the Gastroesophageal
Reflux Disease Questionnaire (GERD-Q).
Methods
All included patients completed the RSS-12 and GERD-Q scales and were considered to
have LPR with an RSS-12 score >11 and GERD with a GERD-Q score >7. Data were analyzed
according to genders (male and female) and age (18-40, 41-60, and >60 years).
Results
A total of 977 patients were included. the mean RSS-12 and GERD-Q score were 11.32±21.34
and 6.31±1.21, and the positive rate of LPR and GERD were 28.76% and 8.90%, respectively.
Males had a higher positive rate of LPR and GERD than females, and there were more
males with LPR who also had GERD. Among those with both LPR and GERD, males had significantly
higher ear-nose-throat (ENT) symptom scores such as hoarseness and excess throat mucus
than females. However, females had significantly higher scores of gastrointestinal
(GI) symptoms, mainly indigestion and abdominal pain, and elder patients (>60 years)
had higher scores of ENT, GI, respiratory symptoms, as well as the impact of symptoms
on quality of life than the young patients (18-40, and 41-60 years).
Conclusion
Patients in the otorhinolaryngology-head and neck surgery clinics have different reflux
characteristics by gender and age in the Chinese population. Males had more severe
ENT-related symptoms of distress, while females had more complaints of GI symptoms.
Older patients had higher scores for ENT, GI and respiratory symptoms.
Key Words
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References
- Evaluation and Management of Laryngopharyngeal Reflux Disease: State of the Art Review.Otolaryngol Head Neck Surg. 2019; 160: 762-782https://doi.org/10.1177/0194599819827488
- Multitime point pepsin testing can double the rate of the diagnosis of laryngopharyngeal reflux.Laryngoscope Investig Otolaryngol. 2021; 6: 1389-1394https://doi.org/10.1002/lio2.700
- Integrative Treatment of Reflux and Functional Dyspepsia in Children.Children (Basel, Switzerland). 2014; 1: 119-133https://doi.org/10.3390/children1020119
- Effect of anti-reflux treatment on gastroesophageal reflux-associated chronic cough: Implications of neurogenic and neutrophilic inflammation.J Asthma. 2020; 57: 1202-1210https://doi.org/10.1080/02770903.2019.1641204
- Validity and Reliability of the Reflux Symptom Index (RSI).J Voice. 2002; 16: 274-277https://doi.org/10.1016/s0892-1997(02)00097-8
- Development and Validation of the Short Version of the Reflux Symptom Score: Reflux Symptom Score-12.Otolaryngol Head Neck Surg. 2021; 164: 166-174https://doi.org/10.1177/0194599820941003
- Development of the GerdQ, a tool for the diagnosis and management of gastro-oesophageal reflux disease in primary care.Aliment Pharmacol Ther. 2009; 30: 1030-1038https://doi.org/10.1111/j.1365-2036.2009.04142.x
- The Relationship Between Gastroesophageal Reflux Disease and Laryngopharyngeal Reflux Based on pH Monitoring.Ear Nose Throat J. 2021; 100: 249-253https://doi.org/10.1177/0145561320971915
- Esophageal Impedance-pH Monitoring and Pharyngeal pH Monitoring in the Diagnosis of Extraesophageal Reflux in Children.Gastroenterology research and practice. 2019; 20196271910https://doi.org/10.1155/2019/6271910
- Laryngopharyngeal Reflux and Atypical Gastroesophageal Reflux Disease.Gastrointest Endosc Clin N Am. 2020; 30: 361-376https://doi.org/10.1016/j.giec.2019.12.004
- The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury.Laryngoscope. 1991; 101: 1-78https://doi.org/10.1002/lary.1991.101.s53.1
- Prevalence and clinical predictors of LPR among patients diagnosed with GERD according to the reflux symptom index questionnaire.Saudi J Gastroenterol. 2018; 24: 236-241https://doi.org/10.4103/sjg.SJG_518_17
- Laryngopharyngeal reflux and GERD.Ann N Y Acad Sci. 2013; 1300: 71-79https://doi.org/10.1111/nyas.12237
- Influence of Age and Sex on Clinical and Therapeutic Features of Laryngopharyngeal Reflux.Otolaryngol Head Neck Surg. 2021; (1945998211020284)https://doi.org/10.1177/01945998211020284
- Gender Specific Differences in Prevalence and Risk Factors for Gastro-Esophageal Reflux Disease.J Korean Med Sci. 2019; 34: e158https://doi.org/10.3346/jkms.2019.34.e158
- Systematic review: ageing and gastro-oesophageal reflux disease symptoms, oesophageal function and reflux oesophagitis.Aliment Pharmacol Ther. 2011; 33: 442-454https://doi.org/10.1111/j.1365-2036.2010.04542.x
- Validity and reliability of the reflux symptom score.Laryngoscope. 2020; 130: E98-E107https://doi.org/10.1002/lary.28017
- A management strategy for GERD based on the Gastroesophageal reflux disease questionnaire (GerdQ).Scand J Gastroenterol. 2008; 43: 34-35
- An epidemiological survey of laryngopharyngeal reflux disease at the otorhinolaryngology-head and neck surgery clinics in China.Eur Arch Otorhinolaryngol. 2020; 277: 2829-2838https://doi.org/10.1007/s00405-020-06045-0
- The prevalence of laryngopharyngeal reflux in the English population.Eur Arch Otorhinolaryngol. 2012; 269: 2219-2225https://doi.org/10.1007/s00405-012-2028-1
- Laryngopharyngeal reflux disease in the Greek general population, prevalence and risk factors.BMC Ear Nose Throat Disord. 2015; 15: 7https://doi.org/10.1186/s12901-015-0020-2
- Development and validation of a laryngopharyngeal reflux questionnaire, the Pharyngeal Reflux Symptom Questionnaire.Scand J Gastroenterol. 2010; 45: 147-159https://doi.org/10.3109/00365520903453166
- Halitosis associated volatile sulphur compound levels in patients with laryngopharyngeal reflux.Eur Arch Otorhinolaryngol. 2016; 273: 1515-1520https://doi.org/10.1007/s00405-016-3961-1
- Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease.Best practice & research Clinical gastroenterology. 2017; 31: 501-508https://doi.org/10.1016/j.bpg.2017.09.004
- [The effect of coffee and tea upon lower esophageal sphincteric function].Laeknabladid. 1995; 81: 484-488
- Inhibitory effect of green tea catechins in combination with sucralfate on Helicobacter pylori infection in Mongolian gerbils.J Gastroenterol. 2004; 39: 61-63https://doi.org/10.1007/s00535-003-1246-0
- Patients with acid, high-fat and low-protein diet have higher laryngopharyngeal reflux episodes at the impedance-pH monitoring.Eur Arch Otorhinolaryngol. 2020; 277: 511-520https://doi.org/10.1007/s00405-019-05711-2
- The Effects of Reflux on the Elderly: The Problems with Medications and Interventions.Otolaryngol Clin North Am. 2018; 51: 779-787https://doi.org/10.1016/j.otc.2018.03.007
- Association of upper gastrointestinal symptoms with functional and clinical charateristics in elderly.World J Gastroenterol. 2011; 17: 3020-3026https://doi.org/10.3748/wjg.v17.i25.3020
- Clinical and psychological characteristics in gastroesophageal reflux disease patients overlapping with laryngopharyngeal reflux symptoms.J Gastroenterol Hepatol. 2019; 34: 1720-1726https://doi.org/10.1111/jgh.14651
- Gender differences in human sepsis.Arch Surg. 1998; 133: 1200-1205https://doi.org/10.1001/archsurg.133.11.1200
- The Number of X Chromosomes Influences Inflammatory Cytokine Production Following Toll-Like Receptor Stimulation.Front Immunol. 2019; 10: 1052https://doi.org/10.3389/fimmu.2019.01052
- Impact of age on laryngopharyngeal reflux disease presentation: a multi-center prospective study.Eur Arch Otorhinolaryngol. 2017; 274: 3687-3696https://doi.org/10.1007/s00405-017-4671-z
- Gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS)–is it one disease or an overlap of two disorders.Dig Dis Sci. 2009; 54: 1829-1834https://doi.org/10.1007/s10620-008-0594-2
Article info
Publication history
Published online: August 16, 2022
Accepted:
July 25,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
