Summary
Objective
The aim of this study was to describe the methodological approaches adopted in experimental
researches in laryngology intervention studies.
Methods
The study was performed as a scoping review using the electronic databases Medline
(PubMed), Web of Science, Embase, BioMed Central and SCOPUS. These databases were
manually searched from 1995 (or its inception) until the most recently published articles
in June 2022. The inclusion criteria were as follows: a) studies performed with animal
models in voice and/or larynx therapy, intervention and/or surgery; b) studies with
participant populations composed with animals; c) studies containing original research;
d) studies performed with at least one objective measurement for treatment and or
intervention; e) studies reporting at least one method of larynx intervention; and
f) publications written in English, Spanish or Portuguese. The exclusion criteria
were as follows: a) studies considering without any objective intervention and or
treatment; b) studies without animal models; and c) studies that reviewed articles
or books. These criteria were set to increase inter-study comparability.
Results
There were found 26 studies that showed that in experimental laryngology. There were
retrieved four main characteristics in the retrieved studies. It was observed five
major groups of experimental models used for assessing vocal folds: dog (38.5%), rat/mouse
(23,1%), pig (23.1%), rabbit (19.2%), human (11.5%), and sheep (3.8%). In addition,
three characteristics were observed: sample (up to 20 subjects 88.5%), type of surgery/intervention
(100%) and duration (up to 30 days 61.5%).
Conclusion
In experimental laryngology, the state of the art is grounded on mainly in dog, rat
and pig in vocal folds assessment. Up to 20 subjects, surgery/intervention and experimental
trial lasting no more than 30 days are frequent methodological approaches in this
research field
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Article info
Publication history
Published online: September 19, 2022
Accepted:
July 26,
2022
Publication stage
In Press Corrected ProofFootnotes
Funding: This study has no specific support. Ana Carolina Nascimento Fernandes received a PhD Student scholarship from the National Counsel of Technological and Scientific Development (CNPq: proc. 142025/2020-8)
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
