Summary
Objectives
To report on the outcomes of unsedated blue laser therapy in female patients with
Reinke's edema.
Study Design
Retrospective chart review.
Methods
A retrospective chart review of female patients undergoing unsedated office-based
blue laser treatment of Reinke's edema between February 2020 and March 2022 at the
Hamdan Voice and Swallowing Unit at the American University of Beirut Medical Center
in Beirut, was conducted. Patients were assessed before and after the procedure with
a follow-up interval of 3–6 weeks. Demographic data included age, history of smoking
and grade of Reinke's edema. Voice outcome measures included the Voice Handicap Index-10
questionnaire, perceptual evaluation (GRBAS scale), acoustic analysis and maximum
phonation time. Vocal fold lesions were evaluated using indirect laryngeal endoscopy.
Results
A total of eight patients were reviewed. The mean age was 59.63 ± 7.98 years. One
patient was lost to follow-up. We report on a total of 10 Reinke's edema lesions treated
with the blue laser. There was a significant decrease in the mean VHI-10 score (14.86
± 5.84–6.71 ± 7.32; P < 0.01) as well as in the means of three perceptual evaluation parameters (G, R,
B; P < 0.05). There was also a nonstatistically significant increase in the mean fundamental
frequency and habitual pitch. Laryngeal examination showed complete regression in
50% of the lesions, and partial regression in the remaining 50%.
Conclusions
Office-based blue laser treatment of Reinke's edema under local anesthesia can be
considered an effective treatment modality as evidenced by improvement in post-procedure
voice outcome measures.
Key Words
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REFERENCES
- Effect of the 532nm pulsed KTP laser in the treatment of Reinke’s edema.The Laryngoscope. 2012; 122: 2786-2792
- Use of the microdebrider for Reinke's edema surgery.The Laryngoscope. 2000; 110: 2114-2116
- Electron microscopic and immunohistochemical investigation of Reinke’s edema.Ann Otol, Rhinol Laryngol. Nov 1999; 108: 1068-1072
- Exudative lesions of Reinke’s space: a terminology proposal.Eur arch oto-rhino-laryngol. 2009; 266: 869-878
- Evaluation of the prevalence of and factors associated with laryngeal diseases among the general population.The Laryngoscope. 2015; 125: 2536-2542
- A Clinico-pathological study of Reinke’s oedema.Indian J otolaryngol Head and Neck surg. 2003; 55: 160-165
- Reinke’s edema.Otolaryngol Clin N Am. 2019; 52: 627-635
- Pathogenic role of Reinke’s edema in snoring and obstructive sleep apnea.J Voice. 2020; 34: 456-459
- Reinke’s edema management and voice outcomes.Laryngoscope Investigative Otolaryngol. 2022; 7: 1042-1050
- Reinke’s edema: phonatory mechanisms and management strategies.Ann Otol, Rhinol Laryngol. 1997; 106: 533-543
Cummings CW. Otolaryngology–head & Neck Surgery: pt. 1. General considerations in head and neck. pt. 2. Face (1 v.). vol 1. Mosby year book; 1998.
- Endoscopic vocal fold microflap: a three-year experience.Ann Otol, Rhinol Laryngol. 1995; 104: 267-273
- In-office procedures for the treatment of benign vocal fold lesions in the awake patient: a contemporary review.The Laryngoscope. 2019; 129: 2131-2138
- Hyaluronidase injection in the vocal folds for vocal hemorrhage, Reinke edema, and hyaluronic acid overinjection: a novel application in the larynx.J Voice. 2018; 32: 492-498
- Un-sedated office-based application of blue laser in vocal fold lesions.J Voice. 2021;
- A clinical study of Reinke’s edema.Auris Nasus Larynx. 1988; 15: 57-78
- Development and validation of the voice handicap index-10.The Laryngoscope. 2004; 114: 1549-1556
- Psycho-acoustic evaluation of voice.Clin examination of voice. 1981; : 81-84
- Office-based photoangiolytic laser treatment of Reinke’s edema: safety and voice outcomes.Otolaryngol–Head and Neck Surg. 2015; 152: 1075-1081
- Quantification of benign lesion regression as a function of 532-nm pulsed potassium titanyl phosphate laser parameter selection.The Laryngoscope. 2011; 121: 590-595
- Office-based laryngeal laser surgery: a review of 443 cases using three wavelengths.Otolaryngol—Head and Neck Surg. 2007; 137: 146-151
- Feasibility and associated limitations of office-based laryngeal surgery using carbon dioxide lasers.JAMA Otolaryngol–Head & Neck Surg. 2017; 143: 485-491
- Unsedated office-based thulium laser therapy in patients with Reinke’s Edema.J Voice. 2020; 36: 134-139
- New 445 nm blue laser for laryngeal surgery combines photoangiolytic and cutting properties.Eur Arch Oto-Rhino-Laryngol. 2018; 275: 1557-1567
- Applications of office-based 445 nm blue laser transnasal flexible laser surgery: a case series and review of practice.Ear, Nose & Throat J. 2021; 100: 105S-112S
- Surgical outcome of low-power-density blue laser for vascular lesions of the vocal fold.J Voice. 2022; (In press)
Article info
Publication history
Published online: October 08, 2022
Accepted:
August 22,
2022
Publication stage
In Press Corrected ProofFootnotes
Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.