Summary
Objective
To investigate the mutually relationship between gastroesophageal reflux disease (GERD)
and laryngopharyngeal reflux disease (LPRD).
Methods
All included patients completed simultaneous 24-hour hypopharyngeal intraluminal multichannel
impedance pH monitoring (24h-MII-pH), Reflux Symptom Index (RSI), and Reflux Finding
Score (RFS). The LPRD diagnosis was based on the occurrence of ≥1 acid or non-acid
hypopharyngeal proximal reflux episode(HRE), GERD was defined as a length of time
>4.0% of the 24-hour recording spent below pH 4.0 or a DeMeester score >14.72. Patients
with both positive LPRD and GERD were classified as LPRD & GERD group, patients with
positive LPRD and negative GERD were classified as ILPRD group, patients with negative
LPRD and positive GERD were classified as IGERD group, and patients with both negative
LPRD and GERD were classified as N group. The differences in clinical characteristics
of reflux between the groups were statistically analyzed.
Results
A total of 437 patients were included, including 248 (56.75%) in the ILPRD group,
98 (22.43%) in the LPRD & GERD group, 23 (5.26%) in the IGERD group, and 68 (15.56%)
in the N group. There was no significant difference between the types of gastroesophageal
reflux in patients with GERD. The number of weak acid/acid/gas/liquid HREs was significantly
more in LPRD & GERD patients than in ILPRD patients (P < 0.01), and the number of distal acid reflux events and Longest distal acid clearance
time were significantly higher in LPRD & GERD patients than in IGERD patients (P > 0.01).
Conclusion
GERD and LPRD are not the same disease but can mutually influence. Combined GERD increased
all types of laryngopharyngeal reflux events in patients with LPRD, whereas combined
LPRD only increased acidic distal reflux events and acid clearance time in patients
with GERD.
Key Words
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Article Info
Publication History
Published online: November 05, 2022
Accepted:
October 12,
2022
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
