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Laryngopharyngeal Reflux Disease and Gastroesophageal Reflux Disease Can Mutually Influence

  • Xiaoyu Wang
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China

    Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui Province, China
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  • Jinhong Zhang
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China
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  • Jiasen Wang
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China
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  • Zhi Liu
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China

    Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui Province, China
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  • Chun Zhang
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China
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  • Jing Zhao
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China
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  • Shizhen Zou
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China
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  • Xin Ma
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China
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  • Jinrang Li
    Correspondence
    Address correspondence and reprint requests to Jinrang Li, MD, Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, 100048. And Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, 230032, Anhui Province, China.
    Affiliations
    Department of otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, China

    Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui Province, China
    Search for articles by this author
Published:November 05, 2022DOI:https://doi.org/10.1016/j.jvoice.2022.10.008

      Summary

      Objective

      To investigate the mutually relationship between gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux disease (LPRD).

      Methods

      All included patients completed simultaneous 24-hour hypopharyngeal intraluminal multichannel impedance pH monitoring (24h-MII-pH), Reflux Symptom Index (RSI), and Reflux Finding Score (RFS). The LPRD diagnosis was based on the occurrence of ≥1 acid or non-acid hypopharyngeal proximal reflux episode(HRE), GERD was defined as a length of time >4.0% of the 24-hour recording spent below pH 4.0 or a DeMeester score >14.72. Patients with both positive LPRD and GERD were classified as LPRD & GERD group, patients with positive LPRD and negative GERD were classified as ILPRD group, patients with negative LPRD and positive GERD were classified as IGERD group, and patients with both negative LPRD and GERD were classified as N group. The differences in clinical characteristics of reflux between the groups were statistically analyzed.

      Results

      A total of 437 patients were included, including 248 (56.75%) in the ILPRD group, 98 (22.43%) in the LPRD & GERD group, 23 (5.26%) in the IGERD group, and 68 (15.56%) in the N group. There was no significant difference between the types of gastroesophageal reflux in patients with GERD. The number of weak acid/acid/gas/liquid HREs was significantly more in LPRD & GERD patients than in ILPRD patients (P < 0.01), and the number of distal acid reflux events and Longest distal acid clearance time were significantly higher in LPRD & GERD patients than in IGERD patients (P > 0.01).

      Conclusion

      GERD and LPRD are not the same disease but can mutually influence. Combined GERD increased all types of laryngopharyngeal reflux events in patients with LPRD, whereas combined LPRD only increased acidic distal reflux events and acid clearance time in patients with GERD.

      Key Words

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