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Characteristics of Laryngopharyngeal Reflux in Patients of Different Genders and Ages

  • Zhi Liu
    Affiliations
    Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, P.R.China

    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Chun Zhang
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Xiaoyu Wang
    Affiliations
    Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, P.R.China

    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Jinhong Zhang
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Lianlian Liu
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Jiasen Wang
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Jing Zhao
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Shizhen Zou
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Xin Ma
    Affiliations
    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
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  • Jinrang Li
    Correspondence
    Address correspondence and reprint requests to Jinrang Li, Navy Clinical College, the Fifth School of Clinical Medicine, and Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Anhui Medical University, Hefei, 230032, Anhui, P.R.China.
    Affiliations
    Navy Clinical College, the Fifth School of Clinical Medicine, Anhui Medical University, Hefei, Anhui, P.R.China

    Department of Otolaryngology, The Sixth Medical Center of PLA General Hospital of Beijing, Beijing, Beijing, P.R.China
    Search for articles by this author
Published:December 23, 2022DOI:https://doi.org/10.1016/j.jvoice.2022.11.035

      Summary

      Objectives

      To investigate the differences in laryngopharyngeal reflux (LPR) characteristics between gender and age groups based on the Reflux Symptom Index (RSI), Reflux Finding Score (RFS) scale and 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH (HEMII-pH) monitoring.

      Methods

      The enrolled were patients with LPR symptoms completed the 24h-HEMII-pH monitoring and divided into two gender groups (male and female) and elderly group (>60 years), middle-aged group (41-60 years) and young group (18-40 years). The total RSI and RFS scores of individuals were counted. Various potential differences as well as incidence of each type of LPR events between gender and age groups were analyzed.

      Results

      A total of 420 patients were included, with 333 (79.3%) diagnosed with LPR confirmed by 24h-HEMII-pH monitoring. Females (n=49) had a statistically higher LPR positivity (91.0% vs. 76.6%, P < 0.01) than males (n=342). Female patients with LPR had significantly higher RSI scores (14.08 ± 6.72 vs. 11.08 ± 4.82, P < 0.001) than male patients. The positive rate of LPR were 82.6%, 80.7% and 63.3% in the elderly, middle-aged and young groups. The Elderly group had significantly lower RSI scores (10.20 ± 4.06 vs. 12.80 ± 6.58, 12.24 ± 5.57, P < 0.001) but higher RFS scores (9.37 ± 3.25 vs. 8.16 ± 3.34, 8.57 ± 2.58, P < 0.05) than the other two groups. The number of acid hypopharyngeal-proximal reflux episodes (HREs) and distal esophageal acid reflux were significantly higher in elderly than in young patients. Except for non-acid gas HREs, the positive rates of other types of HREs were increasing from young to middle-aged to the elderly group (P < 0.05).

      Conclusions

      Female patients with suspected LPR symptoms had a higher positive rate of LPR and RSI score than males. The prevalence of LPR and the number of acid reflux were progressively increasing with age, but the perception of reflux symptoms may diminish.

      Key Words

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