Summary
Objectives
To investigate the differences in laryngopharyngeal reflux (LPR) characteristics between
gender and age groups based on the Reflux Symptom Index (RSI), Reflux Finding Score
(RFS) scale and 24-hour hypopharyngeal-esophageal multichannel intraluminal impedance-pH
(HEMII-pH) monitoring.
Methods
The enrolled were patients with LPR symptoms completed the 24h-HEMII-pH monitoring
and divided into two gender groups (male and female) and elderly group (>60 years),
middle-aged group (41-60 years) and young group (18-40 years). The total RSI and RFS
scores of individuals were counted. Various potential differences as well as incidence
of each type of LPR events between gender and age groups were analyzed.
Results
A total of 420 patients were included, with 333 (79.3%) diagnosed with LPR confirmed
by 24h-HEMII-pH monitoring. Females (n=49) had a statistically higher LPR positivity
(91.0% vs. 76.6%, P < 0.01) than males (n=342). Female patients with LPR had significantly higher RSI
scores (14.08 ± 6.72 vs. 11.08 ± 4.82, P < 0.001) than male patients. The positive rate of LPR were 82.6%, 80.7% and 63.3%
in the elderly, middle-aged and young groups. The Elderly group had significantly
lower RSI scores (10.20 ± 4.06 vs. 12.80 ± 6.58, 12.24 ± 5.57, P < 0.001) but higher RFS scores (9.37 ± 3.25 vs. 8.16 ± 3.34, 8.57 ± 2.58, P < 0.05) than the other two groups. The number of acid hypopharyngeal-proximal reflux
episodes (HREs) and distal esophageal acid reflux were significantly higher in elderly
than in young patients. Except for non-acid gas HREs, the positive rates of other
types of HREs were increasing from young to middle-aged to the elderly group (P < 0.05).
Conclusions
Female patients with suspected LPR symptoms had a higher positive rate of LPR and
RSI score than males. The prevalence of LPR and the number of acid reflux were progressively
increasing with age, but the perception of reflux symptoms may diminish.
Key Words
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Article info
Publication history
Published online: December 23, 2022
Accepted:
November 29,
2022
Publication stage
In Press Corrected ProofFootnotes
Supported by: None.
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
