Summary
Objectives
To compare the effects of botulinum toxin A injection and local glucocorticoid injection
for treating laryngeal contact granuloma and to discuss the indications for both regimens.
Methods
The case data of 50 patients with laryngeal contact granuloma in the outpatient clinic
of the Sixth Medical Center of the PLA General Hospital from January 2020 to December
2021 were reviewed, and the patients were divided into the following two groups according
to the different treatments received: botulinum toxin A injection or local glucocorticoid
injection. Quantitative assessment of the lesion size was performed using Image J
software to compare the efficacy in the two groups.
Results
On comparing the cure rate between the two groups at 3 months after treatment, 72%
of patients in the botulinum toxin A group were cured compared to 40% of patients
in the glucocorticoid group (P = 0.023). On comparing the cure rate between the two groups at 6 months after treatment,
88% of patients in the botulinum toxin A group were cured compared to 64% of patients
in the glucocorticoid group (P = 0.047).
Conclusions
Botulinum toxin A injection is superior to local glucocorticoid injection, and local
glucocorticoid injection is more appropriate for patients who cannot tolerate the
adverse effects of botulinum toxin A.
Key Words
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Article info
Publication history
Published online: January 09, 2023
Accepted:
November 30,
2022
Publication stage
In Press Corrected ProofFootnotes
Supported by: None
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
