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Comparison of the Effects of Botulinum Toxin A Injection and Local Glucocorticoid Injection for Treating Laryngeal Contact Granuloma

  • Yufei Pan
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
    Search for articles by this author
  • Jinrang Li
    Correspondence
    Address correspondence and reprint requests to Jinrang Li , Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China. National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China.
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
    Search for articles by this author
  • Zhi Liu
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
    Search for articles by this author
  • Chun Zhang
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
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  • Lianlian Liu
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
    Search for articles by this author
  • Xiaoyu Wang
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
    Search for articles by this author
  • Jinhong Zhang
    Affiliations
    Department of Otolaryngology Head and Neck Surgery, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, China

    National Clinical Research Center for Otolaryngologic Diseases, Beijing, 100048, China
    Search for articles by this author
Published:January 09, 2023DOI:https://doi.org/10.1016/j.jvoice.2022.11.037

      Summary

      Objectives

      To compare the effects of botulinum toxin A injection and local glucocorticoid injection for treating laryngeal contact granuloma and to discuss the indications for both regimens.

      Methods

      The case data of 50 patients with laryngeal contact granuloma in the outpatient clinic of the Sixth Medical Center of the PLA General Hospital from January 2020 to December 2021 were reviewed, and the patients were divided into the following two groups according to the different treatments received: botulinum toxin A injection or local glucocorticoid injection. Quantitative assessment of the lesion size was performed using Image J software to compare the efficacy in the two groups.

      Results

      On comparing the cure rate between the two groups at 3 months after treatment, 72% of patients in the botulinum toxin A group were cured compared to 40% of patients in the glucocorticoid group (P = 0.023). On comparing the cure rate between the two groups at 6 months after treatment, 88% of patients in the botulinum toxin A group were cured compared to 64% of patients in the glucocorticoid group (P = 0.047).

      Conclusions

      Botulinum toxin A injection is superior to local glucocorticoid injection, and local glucocorticoid injection is more appropriate for patients who cannot tolerate the adverse effects of botulinum toxin A.

      Key Words

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