Summary
Objective
To analyze voice outcomes and lesion regression in patients with Reinke's edema treated
in the office with lasers.
Study design
Systematic review and meta-analysis
Methods
The search was performed in the Medline, Embase, Medline, Cochrane, and Google Scholar
databases using the PRISMA framework. There were no limitations to the year of publication
and the search included studies looking at voice outcomes and lesion evolution of
in-office laser treatment for Reinke's edema measured through voice-handicap index,
acoustic analysis or aerodynamics measures. Risk of bias was assessed using Cochrane's
ROBINS-I tool for observational studies. Data analysis was performed SPSS software
with a significance level of 5%.
Results
The initial search identified 650 articles, 6 of which met the inclusion criteria
and were analyzed. The total number of participants was 58. Meta-analysis showed significant
improvement in VHI-10 scores after in-office laser therapy (95% CI, [-1.46; -0.75]).
It also showed significant improvement in jitter, significant increase in fundamental
frequency (95% CI, [0.52; 1.71]) and significant decrease in lesion size (95% CI,
[-2.03; -0.35]).
Conclusion
Office-based laser therapy is a reliable alternative to the traditional phono-microsurgery
performed in the operating room. Patients show significant improvement in voice outcomes
and laryngeal examination.
Key words
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Article info
Publication history
Published online: January 19, 2023
Accepted:
December 2,
2022
Publication stage
In Press Corrected ProofFootnotes
Funding: None.
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
