Summary
Introduction
The analysis of drugs with adverse effects on voice provides relevant data for the
vocal clinic. It is essential that professionals involved in voice care are aligned
on the topic of voice pharmacovigilance in order to understand adverse effects from
safe and reliable sources.
Objectives
To compare the voice adverse effects of self-reported medications by dysphonic individuals
in different sources of information.
Methods
Descriptive and analytical study based on self-reported active ingredients by dysphonic
individuals and their adverse effects on voice listed in Electronic Database of the
National Health Surveillance Agency of Brazil (Anvisa). Adverse effects were comparatively
analyzed between the Anvisa's Electronic Database and information from the Micromedex
and UpToDate databases. Data were analyzed using descriptive and inferential statistics
that compared the three sources researched in relation to the number of adverse effects
and in relation to the occurrence of adverse effects to the voice.
Results
There was a statistically significant difference between the databases regarding the
occurrence of adverse effects of cough, dyspnea, xerostomia, vomiting and hoarseness,
with a higher occurrence in the UpToDate database. The UpToDate database showed a
statistically significant difference in the amount of drug effects compared to the
Anvisa database (P < 0.001, d = 0.744) and compared to the Micromedex database (P < 0.001, d = 0.598), and in the two cases the mean number of drug effects was higher
for the UpToDate database.
Conclusions
UpToDate proved to be the most suitable source to complement the data from the medication
package inserts at the time of the speech-language pathology assessment. It is recommended
that professionals from all countries involved in voice care seek additional evidence-based
sources of information to gain access to accurate and up-to-date data on adverse effects
of drugs on voice.
Key Words
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Article info
Publication history
Published online: January 06, 2023
Accepted:
December 7,
2022
Publication stage
In Press Corrected ProofFootnotes
Supported by FAPESP, 2019/23069-2.
Identification
Copyright
© 2022 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
