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Medications Adverse Effects on Voice: Comparison Between Different Sources of Information

Published:January 06, 2023DOI:https://doi.org/10.1016/j.jvoice.2022.12.005

      Summary

      Introduction

      The analysis of drugs with adverse effects on voice provides relevant data for the vocal clinic. It is essential that professionals involved in voice care are aligned on the topic of voice pharmacovigilance in order to understand adverse effects from safe and reliable sources.

      Objectives

      To compare the voice adverse effects of self-reported medications by dysphonic individuals in different sources of information.

      Methods

      Descriptive and analytical study based on self-reported active ingredients by dysphonic individuals and their adverse effects on voice listed in Electronic Database of the National Health Surveillance Agency of Brazil (Anvisa). Adverse effects were comparatively analyzed between the Anvisa's Electronic Database and information from the Micromedex and UpToDate databases. Data were analyzed using descriptive and inferential statistics that compared the three sources researched in relation to the number of adverse effects and in relation to the occurrence of adverse effects to the voice.

      Results

      There was a statistically significant difference between the databases regarding the occurrence of adverse effects of cough, dyspnea, xerostomia, vomiting and hoarseness, with a higher occurrence in the UpToDate database. The UpToDate database showed a statistically significant difference in the amount of drug effects compared to the Anvisa database (P < 0.001, d = 0.744) and compared to the Micromedex database (P < 0.001, d = 0.598), and in the two cases the mean number of drug effects was higher for the UpToDate database.

      Conclusions

      UpToDate proved to be the most suitable source to complement the data from the medication package inserts at the time of the speech-language pathology assessment. It is recommended that professionals from all countries involved in voice care seek additional evidence-based sources of information to gain access to accurate and up-to-date data on adverse effects of drugs on voice.

      Key Words

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      REFERENCES

        • Sousa LAO
        • Fonteles MMF
        • Monteiro MP
        • et al.
        Prevalence and characteristics of adverse drug events in Brazil.
        Cad Saúde Pública. 2018; 34e00040017https://doi.org/10.1590/0102-311X00040017
        • Mota DM
        • Vigo A
        • Kuchenbecker RS
        Adverse drug reactions in the Brazilian pharmacovigilance system, 2008 to 2013: descriptive study.
        Cad Saúde Pública. 2019; 35e00148818https://doi.org/10.1590/0102-311X00148818
        • Inácio P
        • Cavaco A
        • Airaksinen M.
        The value of patient reporting to the pharmacovigilance system: a systematic review.
        Br J Clin Pharmacol. 2017; 83: 227-246https://doi.org/10.1111/bcp.13098
        • Mota DM
        • Vigo A
        • Kuchenbecker RS.
        ICD-10 code recommendation for surveillance of adverse drug reactions and intoxications.
        Ciênc saúde coletiva. 2018; 23https://doi.org/10.1590/1413-81232018239.20692016
        • Stachler RJ
        • Francis DO
        • Schwartz SR
        • et al.
        Clinical practice guideline: hoarseness (Dysphonia) (Update).
        Otolaryngol Head Neck Surg. 2018; 158: S1-S42https://doi.org/10.1177/0194599817751031
        • Haft S
        • Farquhar D
        • Carey R
        • et al.
        Anticholinergic use is a major risk factor for dysphonia.
        Ann Otol Rhinol Laryngol. 2015; 124https://doi.org/10.1177/0003489415585867
        • Bock JM.
        Medications and vocal function.
        Otolaryngol Clin N Am. 2019; : 693-702https://doi.org/10.1016/j.otc.2019.03.013
        • Nemr K
        • Silva AC
        • Rodigues DA
        • et al.
        Medications and adverse voice effects.
        J Voice. 2018; 32: e29-515.e39https://doi.org/10.1016/j.jvoice.2017.07.009
        • Cappeta K
        • Beyer C
        • Johnson J
        • et al.
        Meta-analysis: risk of dry mouth with second generation antidepressants.
        Prog Neuro-psychopharmacol Biol Psychiatr. 2018; 84: 282-293https://doi.org/10.1016/j.pnpbp.2017.12.012
        • Miri AK
        • Barthelat F
        • Mongeau L.
        Effects of dehydration on the viscoelastic properties of vocal folds in large deformations.
        J Voice. 2012; 26: 688-697https://doi.org/10.1016/j.jvoice.2011.09.003
        • Sánchez-Sánchez E
        • Fernández-Cerezo FL
        • Díaz-Jimenez J
        • et al.
        Consumption of over-the-counter drugs: prevalence and type of drugs.
        Int J Environ Res Public Health. 2021; 18: 5530https://doi.org/10.3390/ijerph18115530
        • Hersh EV
        • Pinto A
        • Moore PA.
        Adverse drug interactions involving common prescription and over-the-counter analgesic agents.
        Clin Ther. 2007; 29: 2477-2497https://doi.org/10.1016/j.clinthera.2007.12.003
        • Halila GC
        • Czepula AIS
        • Otuki MF
        • et al.
        Review of the efficacy and safety of over-the-counter medicine.
        Braz J Pharm Sci São Paulo. 2015; 51: 403-414https://doi.org/10.1590/S1984-82502015000200018
        • Spiegel JR
        • Hawkshaw M
        • Sataloff RT.
        Dysphonia related to medical therapy.
        Otolaryngol Clin North Am. 2000; : 771-784https://doi.org/10.1016/s0030-6665(05)70243-7
        • Abaza MM
        • Levy S
        • Hawkshaw MJ
        • et al.
        Effects of medications on the voice.
        Otolaryngol Clin North Am. 2007; : 1081-1090https://doi.org/10.1016/j.otc.2007.05.010
        • Pizzol TSD
        • Moraes CG
        • Diello MV
        • et al.
        Use of antidepressant drugs in breastfeeding: assessment of the package inserts' compliance with bibliographic sources based on scientific evidence.
        Cad Saúde Pública. 2019; 35e00041018https://doi.org/10.1590/0102-311X00041018
        • Nemr K
        • Simões-Zenari M
        • Duarte JMT
        • et al.
        Dysphonia risk screening protocol.
        Clinics. 2016; 71: 114-127https://doi.org/10.6061/clinics/2016(03)01
      1. Micromedex - Website: Available at:https://www-micromedexsolutions-com.ez68.periodicos.capes.gov.br/micromedex2/librarian. Accessed on October 10, 2020.

      2. UpToDate - Website: Available at: https://www.uptodate.com/home. Accessed on November 15, 2020.

      3. National Health Surveillance Agency (Anvisa). Electronic Database. 2019. Available at: http://www.anvisa.gov.br/datavisa/fila_bula/index.asp. Accessed September 26, 2019.

        • Sinha P
        • Vandana VP
        • Lewis NV
        • et al.
        Evaluating the effect of risperidone on speech: a cross-sectional study.
        Asian J Psychiatr. 2015; 15: 51-55https://doi.org/10.1016/j.ajp.2015.05.005
        • Thompson AR.
        Pharmacological agents with effects on voice.
        Am J Otolaryngol. 1995; 16: 12-18https://doi.org/10.1016/0196-0709(95)90003-9
        • Cortellini G
        • Caruso C
        • Romano A.
        Aspirin challenge and desensitization: how, when and why.
        Curr Opin Allergy Clin Immunol. 2017; 17: 247-254https://doi.org/10.1097/ACI.0000000000000374
        • Gallo A
        • Clemenzi V
        • Stolfa A.
        • et al.
        The secretory senescence of the oro-pharyngo-laryngeal tract.
        J Gerontol Geriatr. 2020; https://doi.org/10.36150/2499-6564-483
        • Gomes ABP
        • Simões-Zenari M
        • Nemr K.
        Voice of the elderly: does advancing age generate different impacts?.
        CoDAS. 2021; 33e20200126https://doi.org/10.1590/2317-1782/20202020126
        • Gallivan GJ
        • Gallivan KH
        • Gallivan HK.
        Inhaled corticosteroids: hazardous effects on voice-an update.
        J Voice. 2007; 21: 101-111https://doi.org/10.1016/j.jvoice.2005.09.003
        • Blowey DL.
        Diuretics in the treatment of hypertension.
        Pediatric Nephrol. 2016; 31: 2223-2233https://doi.org/10.1007/s00467-016-3334-4
        • Wermelt JA
        • Schunkert H.
        Management of arterial hypertension.
        Herz. 2017; 42: 515-526https://doi.org/10.1007/s00059-017-4574-1
        • Silva BG
        • Chammas TV
        • Zenari MS
        • et al.
        Analysis of possible factors of vocal interference during the teaching activity.
        Rev Saude Publica. 2017; 51: 124https://doi.org/10.11606/S1518-8787.2017051000092
        • Duarte JMDT
        • de Souza GVS
        • Simões-Zenari M
        • et al.
        The actor's voice: vocal performance assessment by different professionals.
        J Voice. 2022; 36 (e1–440.e9)
        • Jahn AF.
        Medical management of the professional singer: an overview.
        Med Problems Performing Artists. 2009; 24 (Available at:) (Accessed April 24, 2022): 3
        • Nallamuthu A
        • Boominathan P
        • Arunachalam R
        • et al.
        Outcomes of vocal hygiene program in facilitating vocal health in female school teachers with voice problems.
        J Voice. 2021; 00018https://doi.org/10.1016/j.jvoice.2020.12.041