Summary
Objectives
To develop a reproducible experimental animal model for sulcus vergeture in rabbits.
Study Design
Experimental animal study.
Material Method
We evaluated three methods of inducing sulcus in twelve New Zealand white rabbits
to produce a sulcus model. Experimental groups comprised: group 1 (n = 4) underwent
submucosal injury following endolaryngeal epithelial incision; group 2 (n = 4) received
submucosal injury via thyrotomy; group 3 (n = 4) received submucosal injury via thyrotomy,
followed with horizontal mucosal lateralization suture. Right vocal folds of the rabbits
underwent surgery to produce sulcus vocalis and left vocal folds were used for the
comparison. In the sixth week after the procedure, the rabbits were sacrificed and
the larynxes were harvested and analyzed histopathologically.
Results
No animals in group 1 or 2 developed sulcus vocalis. Sulcus formation was observed
in all rabbits in group 3, under endoscopic examination and microscopic sulcus formation
was demonstrated for the first, second, and third rabbits. An epithelial depression
area was seen at the glandular ductal opening zone for the fourth rabbit, but it could
also be accepted as a sulcus formation.
Conclusion
We successfully developed a reproducible survival model for sulcus using a submucosal
injury via thyrotomy, followed with a horizontal mucosal lateralization suture. This
model provides the groundwork for future research into the applicability of new approaches
for sulcus management.
Key words
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Article info
Publication history
Published online: January 20, 2023
Accepted:
January 3,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
