Summary
Objective
To explore the glycolytic metabolism of contralateral vocal fold compensation by examining
the glycolytic metabolism of the posterior region of vocal folds in beagles with unilateral
vocal fold immobility disorders and its correlation with acoustic parameters.
Study Design
Prospective animal study.
Setting
Department of Voice
Methods
Ten adult beagles were divided randomly into three groups: a unilateral cricoarytenoid
joint dislocation (UCAJD) group (n = 4), a unilateral vocal fold paralysis (UVFP)
group (n = 4), and a control group (n = 2). Positron emission tomography-computed
tomography (PET/CT) scans of larynx and recordings of vocalizations were collected
4 months after the operations. The maximum standardized uptake values (SUVmax) of
18F-FDG within each posterior region of the vocal folds were obtained from PET/CT
and voice recordings were analyzed for acoustic parameters F0, jitter, shimmer, and
loudness using PRAAT.
Results
In both UCAJD and UVFP groups, a significant increase of SUVmax was observed in the
contralateral vocal fold relative to the impaired fold (P < 0.05). The SUVmax values of the contralateral vocal folds and the SUVmax values
of the impaired vocal folds in the UCAJD, UVFP, and control groups were both found
to be significantly different (P < 0.05). The SUVmax of the contralateral vocal fold may exhibit a potentially negative
correlation with jitter and shimmer, with R2 values of 0.42 and 0.26 and P values of 0.03 and 0.11, respectively.
Conclusion
UCAJD and UVFP can cause enhanced glycolytic metabolism of the contralateral vocal
fold relative to the impaired vocal fold. The SUVmax of the contralateral vocal fold
may be positively correlated with acoustic quality.
Key Words
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Article info
Publication history
Published online: January 30, 2023
Accepted:
January 9,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
