Summary
Objectives
We assessed the safety of flexible fiber-based lasers including the potassium-titanyl-phosphate
(KTP), CO2, and Holmium lasers using a rabbit vocal fold model and provided the safety evidence
of laser before human clinical trial.
Methods
In all, 120 male New Zealand white rabbits were used. Each laser was used to induce
acute and chronic vocal fold injuries in 40 rabbits. The same laser energy with the
same intensity and frequency were used in all cases, and we evaluated outcomes via
surface scanning electron microscopy (SEM) and histological examination 1 day after
injury. Histological and high-speed vocal fold vibration examinations were evaluated
1 month after injury. Surface injury roughness grading was done via SEM, and the Acute
injury ratio and lamina propria (LP) ratio were also calculated. The dynamic glottal
gap was measured through functional analyses based on recordings from a high-speed
digital camera.
Results
The Holmium laser caused significantly more vocal fold damage than did the KTP and
CO2 lasers as revealed by SEM and evaluation of acute and chronic injuries. Functional
analysis with high-speed digital camera indicated that the holmium laser reduced dynamic
glottal gap compared with the normal vocal fold, where the other lasers did not.
Conclusions
The histological and functional analyses of rabbit vocal fold experiments indicated
that fiber-based laryngeal laser surgery for vocal fold lesions could be performed
relatively safely using a KTP or CO2 laser.
Key Words
Abbreviations:
FLS (fiber-based laryngeal laser surgery), KTP (potassium-titanyl-phosphorous), SEM (scanning electron microscopy), LP (lamina propria)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: February 25, 2023
Accepted:
January 23,
2023
Publication stage
In Press Corrected ProofFootnotes
This study was presented at the 92nd Annual Congress of Korean Society of Otorhinolaryngology-Head and Neck Surgery, 2018 Spring Meeting of Korean Association of Otorhinolaryngologists in conjunction with International Congress of ORL-HNS 2018 in Seoul, Republic of Korea at April 29, 2018.
Identification
Copyright
© 2023 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
