Summary
Objectives
Although there are many reports of voice improvement with intracordal trafermin (a
basic fibroblast growth factor) injections under local anesthesia, few papers have
documented the safety of trafermin. Therefore, we aimed to investigate whether trafermin
is safer than control drugs (triamcinolone acetonide) early after intracordal injection
under local anesthesia.
Methods
We conducted a retrospective review from the medical records of patients who underwent
intracordal injection with trafermin and triamcinolone acetonide under local anesthesia
at our institution. Early postinjective complications were defined as changes in vital
signs and chief complaints early after intracordal injection.
Results
A total of 699 and 297 patients underwent intracordal injection under local anesthesia
with trafermin and triamcinolone acetonide, respectively. Of these, 227 and 130 patients
had early postinjective complications with trafermin and triamcinolone acetonide,
retrospectively. The most common complications occurring with trafermin was increased
blood pressure in 39 cases (5.58%): 17 cases (2.43%) of blood pressure increase of
≥20 mm Hg. Other complications included pharyngeal discomfort in 37 (5.29%), lightheadedness
in 33 (4.72%), and phlegm discharge in 29 (4.15%). Triamcinolone acetonide caused
pharyngeal discomfort in 28 patients (9.43%), phlegm discharge in 17 patients (5.72%),
lightheadedness in 12 patients (4.04%), sore throat in 11 patients (3.70%), increased
blood pressure in 10 patients (3.37%): 7 cases (2.36%) of blood pressure increase
of ≥20 mm Hg, and dizziness in seven patients (2.36%). Statistical analysis of the
complications between trafermin and triamcinolone acetonide showed no significant
differences.
Conclusions
The proportion of early postinjective complications from intracordal injection of
trafermin is no significant difference in that of triamcinolone acetonide. The results
suggest that the early postinjective complications are not due to the drug action
of trafermin, but rather to complications from the intracordal injection procedures.
Intracordal trafermin injection may be safe in the short term.
Key Words
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Article info
Publication history
Published online: April 06, 2023
Accepted:
March 7,
2023
Publication stage
In Press Corrected ProofIdentification
Copyright
© 2023 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
