Summary
Objective
Although intracordal trafermin injection has been performed in the treatment of age-related
vocal fold atrophy, the effects of single high dose trafermin injections are unknown.
In this study, we examined the 1 year outcomes and longitudinal changes in voice improvement
with single high dose intracordal trafermin injections.
Study Design
Retrospective study with approval by our Ethics Committee.
Methods
The medical records of 34 patients who underwent single high dose (50ug per side)
intracordal trafermin injections under local anesthesia for vocal fold atrophy were
retrospectively reviewed at 1 month pre-injection and 1 month, 6 months and 1 year
post injection.
Results
Maximum phonation time (MPT), pitch range (PR), Japanese version of voice handicap
index (VHI), grade of GRBAS evaluation, and jitter% improved significantly at 1-year
post-injection compared to 1-month pre-injection. MPT and PR improved as early as
1-month post-injection and continued to improve most at 1-year post-injection. VHI
showed negative progression from 6-months to 1-year post-injection, during which time
the speaking fundamental frequency (SFF) changed to the high pitch in men.
Conclusions
Single high dose intracordal trafermin injections can be expected to improve voice
in the early post-injection period and to maintain its effect for 1 year. SFF may
play a role in worsening VHI in men.
Level of evidence
level 4.
Key Words
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Article info
Publication history
Published online: May 02, 2023
Accepted:
March 28,
2023
Publication stage
In Press Corrected ProofFootnotes
This work was supported by JSPS KAKENHI Grant-in-Aid for Young Scientists Number JP 20K18261.
Identification
Copyright
© 2023 The Voice Foundation. Published by Elsevier Inc. All rights reserved.
