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    • Medications treating or affecting the larynx

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    • Research Article25
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    • Branski, Ryan C2
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    • Journal of Voice28

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    • Research Article

      Laryngeal Mucosal Reaction during Bronchial Histamine Challenge Test Visualized by Videolaryngostroboscopy

      Journal of Voice
      Vol. 31Issue 4p470–475Published online: December 14, 2016
      • Maaria Ansaranta
      • Ahmed Geneid
      • Paula Kauppi
      • Leo Pekka Malmberg
      • Erkki Vilkman
      Cited in Scopus: 3
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        To examine the changes in the larynx, as well as self-reported voice and throat symptoms, among patients undergoing a histamine challenge test. Thus, to understand the possible clinical effects of histamine on the larynx.
        Laryngeal Mucosal Reaction during Bronchial Histamine Challenge Test Visualized by Videolaryngostroboscopy
      • Review Article

        Inhaled Corticosteroids and Voice Problems. What Is New?

        Journal of Voice
        Vol. 31Issue 3p384.e1–384.e7Published online: October 11, 2016
        • Nikolaos Spantideas
        • Eirini Drosou
        • Anastasia Bougea
        • Dimitrios Assimakopoulos
        Cited in Scopus: 8
        Online Extra
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          Voice problems are the most common and most annoying local side effect of inhaled corticosteroids (ICS), affecting not only patients' treatment compliance but also their quality of life. The literature is very poor regarding prevalence, mechanism, prevention, and management of voice problems attributed to ICS use and especially for the new ICS, ciclesonide. Prevalence of dysphonia seems to be less common with the use of ciclesonide and beclomethasone dipropionate.
        • Research Article

          Effects of Radioactive Iodine Ablation Therapy on Voice Quality

          Journal of Voice
          Vol. 31Issue 1p94–96Published online: July 1, 2016
          • İmran Aydoğdu
          • Yavuz Atar
          • Ziya Saltürk
          • Hüseyin Sarı
          • Enes Ataç
          • Zeynep Aydoğdu
          • and others
          Cited in Scopus: 2
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            The goal of this study was to evaluate the effects of radioactive iodine ablation therapy on voice quality of patients diagnosed with well-differentiated thyroid carcinoma.
          • Research Article

            The Risk of Vocal Fold Atrophy after Serial Corticosteroid Injections of the Vocal Fold

            Journal of Voice
            Vol. 30Issue 6p762.e11–762.e13Published online: November 24, 2015
            • Lucy L. Shi
            • Laureano A. Giraldez-Rodriguez
            • Michael M. Johns III
            Cited in Scopus: 10
            Online Extra
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              The aim of this study was to illustrate the risk of vocal fold atrophy in patients who receive serial subepithelial steroid injections for vocal fold scar.
              The Risk of Vocal Fold Atrophy after Serial Corticosteroid Injections of the Vocal Fold
            • Research Article

              Botulinum Toxin A for Treatment of Contact Granuloma

              Journal of Voice
              Vol. 30Issue 6p741–743Published online: August 19, 2015
              • Taner Yılmaz
              • Bahar Kayahan
              • Rıza Önder Günaydın
              • Oğuz Kuşçu
              • Tevfik Sözen
              Cited in Scopus: 14
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                Contact granuloma has been associated with voice abuse, laryngopharyngeal reflux, and habitual throat clearing. It has a high propensity for persistence and recurrence. Treatment options included voice therapy and antireflux measures. Surgical excision has been considered in patients who do not respond to medical management. In this research, we aimed to present our experience with botulinum toxin injection only.
              • Research Article

                Laryngeal Side Effects of Tyrosine Kinase Inhibitors

                Journal of Voice
                Vol. 30Issue 5p606–610Published online: August 10, 2015
                • Sharon Ovnat Tamir
                • Dafna Gershnabel Milk
                • Yehudah Roth
                • Udi Cinamon
                • Asher Winder
                • Ronen Brenner
                • and others
                Cited in Scopus: 3
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                  Tyrosine kinase inhibitors (TKIs) are common targeted drugs, used in the treatment of hematological and solid malignancies. These drugs present a multitude of potential adverse effects. Laryngeal manifestations, including laryngeal edema, secondary to TKIs treatment have not been well studied, despite their potential lethality.
                • Research Article

                  The Use of the Quadrivalent Human Papillomavirus Vaccine (Gardasil) as Adjuvant Therapy in the Treatment of Recurrent Respiratory Papilloma

                  Journal of Voice
                  Vol. 29Issue 2p223–229Published online: January 22, 2015
                  • David L. Young
                  • Michael M. Moore
                  • Lucinda A. Halstead
                  Cited in Scopus: 49
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                    To examine the effect of the quadrivalent human papillomavirus vaccine, Gardasil, on the disease course of patients with recurrent respiratory papillomatosis (RRP).
                    The Use of the Quadrivalent Human Papillomavirus Vaccine (Gardasil) as Adjuvant Therapy in the Treatment of Recurrent Respiratory Papilloma
                  • Research Article

                    Pyridostigmine for Reversal of Severe Sequelae From Botulinum Toxin Injection

                    Journal of Voice
                    Vol. 28Issue 6p830–834Published online: July 5, 2014
                    • David L. Young
                    • Lucinda A. Halstead
                    Cited in Scopus: 10
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                      Botulinum toxin is used to treat a wide range of dystonias in the head and neck. Occasionally, patients receiving laryngeal botulinum toxin experience severe dysphagia, dyspnea, or even distant and autonomic symptoms. Rarely, these patients may require hospitalization with possible intubation and placement of nasogastric tubes. Botulinum antitoxin is not readily available and ineffective once symptoms have progressed, so patients must wait until the toxin wears off over weeks to months. Pyridostigmine prevents the breakdown of acetylcholine at the neuromuscular junction, thus making more neurotransmitter available for the muscles.
                    • Research Article

                      Glucocorticoids for Vocal Fold Disease: A Survey of Otolaryngologists

                      Journal of Voice
                      Vol. 28Issue 1p82–87Published online: September 19, 2013
                      • Nandini Govil
                      • Benjamin Y. Rafii
                      • Benjamin C. Paul
                      • Ryan Ruiz
                      • Milan R. Amin
                      • Ryan C. Branski
                      Cited in Scopus: 14
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                        Glucocorticoids (GCs) are commonly used in the treatment of laryngeal disorders despite the absence of clear guidelines regarding their use. We sought to assess clinical practice patterns regarding GC use for various vocal fold diseases and to ascertain factors underlying the selection of particular GCs for different vocal fold pathology.
                        Glucocorticoids for Vocal Fold Disease: A Survey of Otolaryngologists
                      • Research Article

                        The Effect of Oral Topical Anesthesia on the Characteristics of Voice

                        Journal of Voice
                        Vol. 28Issue 1p92–97Published online: September 19, 2013
                        • Amanda Hu
                        • Jaime Eaglin Moore
                        • Bridget Rose
                        • Stephanie Fort
                        • Edward J. Gracely
                        • Robert T. Sataloff
                        Cited in Scopus: 0
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                          Although oral topical anesthesia is used routinely before rigid laryngeal endoscopy, no study has determined whether oral topical anesthesia changes voice quality. Our goal was to determine the effects of topical anesthesia on voice.
                        • Research Article

                          Botulinum Toxin in the Management of Laryngeal Tics

                          Journal of Voice
                          Vol. 22Issue 2p251–256Published online: October 23, 2006
                          • Daniel A. Vincent Jr.
                          Cited in Scopus: 24
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                            The objective of the study was to demonstrate the utility of botulinum toxin (BTX; Botox: Allergan Pharmaceuticals, Irvine, CA) type A injections for symptom reduction in laryngeal tics. The study consisted of case studies and literature review. Case histories of two patients with laryngeal tics are presented. Treatment was administered using BTX type A injected into the thyroarytenoid muscles using electromyographic guidance or via direct laryngoscopy. Treatment outcomes were measured using clinical rating scales with a range from 0 (no response) to 4 (maximal response).
                          • Review Article

                            Cytotoxic Agents in the Treatment of Laryngeal Sarcoidosis: A Case Report and Review of the Literature

                            Journal of Voice
                            Vol. 20Issue 3p481–484Published online: February 14, 2006
                            • Yuri Agrawal
                            • David A. Godin
                            • Peter C. Belafsky
                            Cited in Scopus: 18
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                              Sarcoidosis is a multisystem disease with various clinical manifestations. It is characterized primarily on a histopathologic basis by the presence of noncaseating granulomata. Laryngeal involvement reportedly occurs in 3–5% of cases, and it is typically localized to the supraglottic region. Patients often present with hoarseness, dysphagia, stridor, or dyspnea. Laryngoscopy typically demonstrates a pale, edematous epiglottis studded with nodules.1 Tissue biopsy reveals the classic noncaseating granuloma; however, the finding is not diagnostic.
                              Cytotoxic Agents in the Treatment of Laryngeal Sarcoidosis: A Case Report and Review of the Literature
                            • Research Article

                              Inhaled Corticosteroids: Hazardous Effects on Voice—An Update

                              Journal of Voice
                              Vol. 21Issue 1p101–111Published online: January 30, 2006
                              • Gregory J. Gallivan
                              • K. Holly Gallivan
                              • Helen K. Gallivan
                              Cited in Scopus: 45
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                                Inhaled corticosteroids (ICS) have become the prevalent treatment in asthmatics. Hazards to voice are under-recognized. A total of 38 patients with voice complaints associated with the use of ICS were assessed by 79 strobovideolaryngoscopy (SVL) examinations, 24 single and 14 multiple SVL. Hoarseness and dysphonia were the primary reasons for referral. The ICS initially used most frequently was Advair Diskus (fluticasone propionate and salmeterol-inhalation powder-[IP]) in 22 patients, followed by Flovent (fluticasone propionate inhalation aerosol-pressurized metered-dose inhaler-[PMDI]) in 11.
                              • Research Article

                                Double-Blind Study on the Effects of Topical Anesthesia on Laryngeal Secretions

                                Journal of Voice
                                Vol. 20Issue 2p282–290Published online: November 28, 2005
                                • Joy Walsh
                                • Ryan C. Branski
                                • Katherine Verdolini
                                Cited in Scopus: 3
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                                  The application of topical anesthesia to the oropharynx is a common clinical practice during oral and nasal laryngoscopy. Clinically, questions have been raised about whether topical anesthesia alters laryngeal secretions, which distorts clinical impressions. A double-blind, placebo controlled design was employed to address this issue. Ten premenopausal women with healthy vocal folds and 10 premenopausal women with phonotraumatic lesions underwent oral videolaryngoscopic examinations on subsequent days under both anesthesia and placebo conditions, in counterbalanced order.
                                  Double-Blind Study on the Effects of Topical Anesthesia on Laryngeal Secretions
                                • Research Article

                                  Recurrent Dysphonia and Acitretin

                                  Journal of Voice
                                  Vol. 20Issue 4p642–643Published online: November 9, 2005
                                  • N. Petitpain
                                  • J. Pouaha
                                  • F. Cosserat
                                  • N. Gambier
                                  • F. Truchetet
                                  • J.-F. Cuny
                                  Cited in Scopus: 3
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                                    We report the case of a woman complaining of dysphonia while she was treated by acitretin. Her symptoms totally regressed after drug withdrawal and reappeared when acitretin was reintroduced. To our knowledge, this is the first case of acitretin-induced dysphonia. This effect may be related to the pharmacological effect of this drug on mucous membranes.
                                  • Research Article

                                    Efficacy of cidofovir injection for the treatment of recurrent respiratory papillomatosis

                                    Journal of Voice
                                    Vol. 18Issue 4p551–556Published online: September 28, 2004
                                    • Annie S. Lee
                                    • Clark A. Rosen
                                    Cited in Scopus: 39
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                                      To evaluate the efficacy of intralesional cidofovir injection for the treatment of recurrent respiratory papillomatosis (RRP). It is a prospective, open-label study design. This prospective study included 16 RRP patients, ages 9 to 68 years, who were treated with intralesional injections of cidofovir combined with surgical excision of RRP. The disease states of the patients pretreatment and posttreatment were assessed by assigning RRP severity scores, examining the need for any surgical excision of RRP, and evaluating the presence of RRP upon long-term follow-up.
                                      Efficacy of cidofovir injection for the treatment of recurrent respiratory papillomatosis
                                    • Research Article

                                      Voice problems as side effects of inhaled corticosteroids in asthma patients—a prevalence study

                                      Journal of Voice
                                      Vol. 18Issue 3p403–414Published in issue: September, 2004
                                      • Eva Ihre
                                      • Olle Zetterström
                                      • Elisabeth Ihre
                                      • Britta Hammarberg
                                      Cited in Scopus: 39
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                                        Voice disturbances in asthma patients may be caused by inhaled corticosteroids. In order to study the prevalence of such voice disturbances, a questionnaire was delivered to asthma patients at three asthma and allergy departments in Stockholm. The questionnaire consisted of 25 questions concerning the asthma disease symptoms, medication, voice function, and voice disturbances. A total of 350 questionnaires were delivered. Response frequency was 80%. There was a significant positive correlation between inhalation of cortison and voice disturbances.
                                        Voice problems as side effects of inhaled corticosteroids in asthma patients—a prevalence study
                                      • Research Article

                                        Indole-3-Carbinol for recurrent respiratory papillomatosis: long-term results

                                        Journal of Voice
                                        Vol. 18Issue 2p248–253Published in issue: June, 2004
                                        • Clark A. Rosen
                                        • Paul C. Bryson
                                        Cited in Scopus: 111
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                                          We report the results of a clinical study using Indole-3-Carbinol (I3C) for the treatment of recurrent respiratory papillomatosis (RRP). I3C is abundant in cruciferous vegetables and has been shown to decrease papillomatous growth in cell cultures and be effective in an animal model of RRP. This is a prospective, open-label study design. Patients with RRP were enrolled from September 1996 to August 2001 and treated with I3C (adult dose of 200 mg PO BID). All patients underwent complete surgical removal and then started I3C.  
                                        • Articles

                                          Response of Asthma-Related Voice Dysfunction to Allergen Immunotherapy: A Case Report of Confirmation by Methacholine Challenge

                                          Journal of Voice
                                          Vol. 15Issue 4p558–560Published in issue: December, 2001
                                          • John R Cohn
                                          • Robert T Sataloff
                                          • Catherine Branton
                                          Cited in Scopus: 18
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                                            Professional singers and other serious voice users are particularly susceptible to alterations in their vocal apparatus. As the support for vocalization, lung function is an essential element of the production of speech and song. Patients have been described who presented with voice complaints along with minimal or no abnormalities on spirometry, but responded to conventional bronchodilator and other asthma therapy. It was proposed that this represented an exercise-induced asthmalike condition, brought on by the hyperventilation associated with performing.
                                          • Research Article

                                            Dysphonia associated with inhaled steroids

                                            Journal of Voice
                                            Vol. 14Issue 4p581–588Published in issue: December, 2000
                                            • J.A. Lavy
                                            • G. Wood
                                            • J.S. Rubin
                                            • M. Harries
                                            Cited in Scopus: 49
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                                              The use of inhaled steroids in the treatment of asthma is not without its complications. In some studies up to 50% of such patients complain of oropharyngeal and voice problems. We present the findings in 22 patients complaining of dysphonia who underwent videostrobolaryngoscopy (VSL) and computerized speech analysis. A number of abnormalities were identified. On VSL, these included mucosal changes (noted in 58%), apposition abnormalities (noted in 43%), and supraglottic hyperfunction (noted in 40%).
                                            • Research Article

                                              “Alternative medical therapy” use among singers: Prevalence and implications for the medical care of the singer

                                              Journal of Voice
                                              Vol. 14Issue 3p398–409Published in issue: September, 2000
                                              • Jason B. Surow
                                              • Jeanette Lovetri
                                              Cited in Scopus: 8
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                                                Singers are extremely conscious of health problems that affect their voices and well-being and often take an active role in seeking care for these problems. They frequently seek treatment from providers or with modalities considered “alternative” to traditional medical care. A survey of singers was completed to elucidate their attitudes and practices regarding “alternative modalities” of medical care. Frequently singers will self-medicate or take advice from people not well versed in the special needs of a professional voice user.
                                              • Research Article

                                                The treatment of essential voice tremor with botulinum toxin A: A longitudinal case report

                                                Journal of Voice
                                                Vol. 14Issue 3p410–421Published in issue: September, 2000
                                                • Paul Warrick
                                                • Christopher Dromey
                                                • Jonathan Irish
                                                • Lisa Durkin
                                                Cited in Scopus: 49
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                                                  The purpose of this study was to evaluate the effects of bilateral botulinum toxin injection into the thyroarytenoid (TA) muscles of a patient with essential voice tremor. Acoustic and aerodynamic data were collected weekly over a 16-week period. Flexible nasolaryngoscopy was performed prior to injection and 2, 6, 10, and 16 weeks postinjection. Perceptual analyses of the acoustic and nasolaryngoscopic data were performed. A reduction in frequency tremor and, to a lesser extent, amplitude tremor was observed during the 1–10 week period.
                                                • Rapid Communication

                                                  Botulinum toxin injection in the treatment of vocal fold paralysis associated with multiple sclerosis: A case report

                                                  Journal of Voice
                                                  Vol. 13Issue 2p274–279Published in issue: June, 1999
                                                  • Eugene Rontal
                                                  • Michael Rontal
                                                  • John Wald
                                                  • David Rontal
                                                  Cited in Scopus: 19
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                                                    Botulinum toxin has been demonstrated clinically to be an effective treatment for a variety of laryngeal problems, most notably spasmodic dysphonia. As in other movement disorders, the theory behind the injection of this substance in the larynx has been a weakening of the vocal fold musculature to relieve uncoordinated and spasmodic movement of the vocal folds, presumably rebalancing the forces within the intralaryngeal musculature. Recently, this concept was applied to help reposition the arytenoid cartilage in acute and long-standing anteromedial cricoarytenoid dislocations.
                                                  • Research Article

                                                    Does botulinum toxin alter laryngeal secretionsand mucociliary transport?

                                                    Journal of Voice
                                                    Vol. 12Issue 3p389–398Published in issue: 1998
                                                    • Kimberly V. Fisher
                                                    • Cheryl L. Giddens
                                                    • Steven D. Gray
                                                    Cited in Scopus: 6
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                                                      Localized botulinum toxin injection disrupts cholinergic transmissionand has potential to cause focal dysautonomia. Mucociliary transport and laryngeal secretions are thought to be mediated in part by autonomic, cholinergic transmission. We questioned whether patients who receive Botox® injection for adductor spasmodic dysphonia (ADSD) report postinjection symptoms possibly related to altered mucociliary clearance or laryngeal secretions. Medical histories, audiotaped interviews, and symptom ratings were retrospectively examined for 29 patients with ADSD who were followed after one or more Botox injections.
                                                    • Research Article

                                                      Vocal fundamental frequency measures as a reflection of tumor response to chemotherapy in patients with advanced laryngeal cancer

                                                      Journal of Voice
                                                      Vol. 11Issue 1p33–39Published in issue: March, 1997
                                                      • Robert F. Orlikoff
                                                      • Dennis H. Kraus
                                                      • Louis B. Harrison
                                                      • Margaret L. Ho
                                                      • Carolyn J. Gartner
                                                      Cited in Scopus: 7
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                                                        The fundamental frequency (F0) characteristics of 19 male patients with advanced laryngeal cancer, treated with cisplatin-based chemotherapy as part of a Larynx Preservation Protocol (LPP), were measured before each of three cycles of chemotherapy received before definitive radiotherapy (RT). In these select patients, for whom chemotherapy resulted in ⩾50% decrease in the tumor bulk, it was found that mean F0 was essentially unaffected by the disease and did not change over the course of chemotherapy, although the cycle of their treatment could be differentiated by both speaking F0 variability (pitch sigma) and F0 perturbation (fitter).
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